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PubMed Central
by Haynes, Emma; Taylor, Kate P; Durey, Angela; Bessarab, Dawn; Thompson, Sandra C
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This article is from International Journal for Equity in Health , volume 13 . Abstract Introduction: The substantial gap in life expectancy between Indigenous and non-Indigenous Australians has been slow to improve, despite increased dedicated funding. Partnerships between Australian Indigenous and mainstream Western biomedical organisations are recognised as crucial to improved Indigenous health outcomes. However, these partnerships often experience challenges, particularly in the context of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169641
PubMed Central
by Shen, Na; Yan, Fei; Pang, Jiuxia; Wu, Lai-Chu; Al-Kali, Aref; Litzow, Mark R.; Liu, Shujun
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This article is from Oncotarget , volume 5 . Abstract Nucleolin overexpression and DNA hypermethylation have been implicated in cancer pathogenesis, but whether and how these aberrations cooperate in controlling leukemia cell fate remain elusive. Here, we provide the first mechanistic insights into the role of nucleolin in leukemogenesis through creating a DNA hypermethylation profile in leukemia cells. We found that, in leukemia patients, nucleolin levels are significantly elevated and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170608
PubMed Central
by Lim, Jae Hoon
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This article is from Korean Journal of Radiology , volume 15 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170170
PubMed Central
by Brunkwall, Louise; Ericson, Ulrika; Hellstrand, Sophie; Gullberg, Bo; Orho-Melander, Marju; Sonestedt, Emily
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This article is from Food & Nutrition Research , volume 57 . Abstract Background: Earlier studies have indicated that the fat mass and obesity-associated gene (FTO) is not only associated with BMI and weight but also with appetite and dietary intake. Objectives: We investigated if the FTO rs9939609 associates with food preferences in healthy adults with no cancer, cardiovascular disease, or diabetes. Additionally, we challenged the question if the associations are modified by obesity status...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625705
This article is from Journal of Pharmacy & Bioallied Sciences , volume 6 . Abstract Although most studies in immunology have used inbred mice as the experimental model to study fundamental immune mechanisms they have been proven to be limited in their ability to chart complex functional immune pathways, such as are seen in outbred populations of humans or animals. Translation of the findings from inbred mouse studies into practical solutions in therapeutics or the clinic has been remarkably...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895287
PubMed Central
by Rucktooa, Prakash; Haseler, Claire A.; van Elk, Rene; Smit, August B.; Gallagher, Timothy; Sixma, Titia K.
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This article is from The Journal of Biological Chemistry , volume 287 . Abstract Background: Cytisine and varenicline are smoking cessation drugs binding to nicotinic receptors (nAChRs).Results: We studied crystal structures of cytisine and varenicline with AChBP and analyzed binding of α4β2-like or α7-like AChBP mutants to cytisine.Conclusion: Ligand selectivity relies on residues beyond the binding site primary shell.Significance: These structures will contribute to designing novel...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390607
PubMed Central
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This article is from BMC Pregnancy and Childbirth , volume 11 . Abstract Background: Decision-making can be based on treatment preferences of the patient, the doctor, or by guidelines based on lay people's preferences. We compared valuations assigned by three groups: patients, obstetrical care professionals, and laypersons, for health states involving both mother and (unborn) child. Our aim was to compare the valuations of different groups using different valuation methods and complex obstetric...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226638
PubMed Central
by Rasschaert, Freya; Decroo, Tom; Remartinez, Daniel; Telfer, Barbara; Lessitala, Faustino; Biot, Marc; Candrinho, Baltazar; Van Damme, Wim
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This article is from BMC Public Health , volume 14 . Abstract Background: To improve retention in antiretroviral therapy (ART), lessons learned from chronic disease care were applied to HIV care, providing more responsibilities to patients in the care of their chronic disease. In Tete - Mozambique, patients stable on ART participate in the ART provision and peer support through Community ART Groups (CAG). This article analyses the evolution of the CAG-model during its implementation process....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990026
PubMed Central
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This article is from BMC Cancer , volume 14 . Abstract Background: While glucocorticoids and the liganded glucocorticoid receptor (GR) have a well-established role in the maintenance of differentiation and suppression of apoptosis in breast tissue, the involvement of unliganded GR in cellular processes is less clear. Our previous studies implicated unliganded GR as a positive regulator of the BRCA1 tumour suppressor gene in the absence of glucocorticoid hormone, which suggested it could play a...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021255
PubMed Central
by Allen, Kim D.; Gourov, Andrei V.; Harte, Christopher; Gao, Peng; Lee, Clarice; Sylvain, Darlene; Splett, Joshua M.; Oxberry, William C.; van de Nes, Paula S.; Troy-Regier, Matthew J.; Wolk, Jason; Alarcon, Juan M.; Hernandez, A. Ivan
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This article is from PLoS ONE , volume 9 . Abstract Long-term memory (LTM) formation requires new protein synthesis and new gene expression. Based on our work in Aplysia, we hypothesized that the rRNA genes, stimulation-dependent targets of the enzyme Poly(ADP-ribose) polymerase-1 (PARP-1), are primary effectors of the activity-dependent changes in synaptic function that maintain synaptic plasticity and memory. Using electrophysiology, immunohistochemistry, pharmacology and molecular biology...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121280
PubMed Central
by Telianidis, Jonathon; Hung, Ya Hui; Materia, Stephanie; Fontaine, Sharon La
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This article is from Frontiers in Aging Neuroscience , volume 5 . Abstract Over the past two decades there have been significant advances in our understanding of copper homeostasis and the pathological consequences of copper dysregulation. Cumulative evidence is revealing a complex regulatory network of proteins and pathways that maintain copper homeostasis. The recognition of copper dysregulation as a key pathological feature in prominent neurodegenerative disorders such as Alzheimer’s,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750203
This article is from Indian Journal of Pharmaceutical Sciences , volume 75 . Abstract A sensitive method based on the fluorescence enhancement was developed for the determination of rutin. It was found that the rutin could form a fluorescent complex with ytterium (III), and the fluorescence intensity of which could be enhanced by sodium dodecyl benzene sulfonate. Under the optimum conditions, the enhanced fluorescence intensity was in proportion to the concentration of rutin in the range of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877527
PubMed Central
by Allameh, Zahra; Rouholamin, Safoura; Adibi, Atusa; Mehdipour, Mehrnaz; Adeli, Maryam
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This article is from International Journal of Preventive Medicine , volume 4 . Abstract Background:: Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder associated with cardiovascular disease (CVD) risk factors and metabolic disturbances and a genetically heterogeneous disease. Intima-media thickness (IMT) is an indicator of atherosclerosis. This study aimed to determine the relation between IMT and PCOS in women. Methods:: This cross-sectional study was performed on 44...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883250
PubMed Central
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This article is from Nigerian Medical Journal : Journal of the Nigeria Medical Association , volume 55 . Abstract Background:: Although maximal heart rate (HR)max is used widely to assess exercise intensity in sport training and particularly in various team sports, there are limited data with regards to the use of age-based prediction equations of HRmax in sport populations. The aim of this study was to compare the measured-HRmax with three prediction equations (Fox-HRmax = 220-age and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124545
PubMed Central
by Khozeimeh, Faezeh; Mohammadpour, Mehrnaz; Taghian, Mehdi; Naemy, Vahid
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This article is from Dental Research Journal , volume 11 . Abstract Background:: Candida albicans is the most common opportunistic fungal species in the oral cavity. Various factors associated with C. albicans infection have been evaluated so far. In some studies, the relationship between the blood group antigens and C. albicans has been discussed. The aim of this study was to assess mean C. albicans colony counts in the saliva of healthy subjects and its relationship with ABO blood groups....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052651
PubMed Central
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This article is from Annals of Indian Academy of Neurology , volume 14 . Abstract Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease in adults. Typically, patients with ALS develop progressive weakness resulting, eventually, in respiratory muscle paralysis and death in 3-5 years after the onset of the disease. No definite therapy currently exists for ALS. The biologic basis of the disease is unknown. However, ALS research has taken a dramatic turn over the last 3 years....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271459
PubMed Central
by Luo, Jake; Young, Amanda; Kopcke, Felix; Prokosch, Hans-Ulrich
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This article is from Journal of Medical Internet Research , volume 16 . Abstract Background: Medical progress depends on the evaluation of new diagnostic and therapeutic interventions within clinical trials. Clinical trial recruitment support systems (CTRSS) aim to improve the recruitment process in terms of effectiveness and efficiency. Objective: The goals were to (1) create an overview of all CTRSS reported until the end of 2013, (2) find and describe similarities in design, (3) theorize on...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128959
PubMed Central
by Eigler, Tamar; Ben-Shlomo, Anat; Zhou, Cuiqi; Khalafi, Ramtin; Ren, Song-Guang; Melmed, Shlomo
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This article is from Molecular Endocrinology , volume 28 . Abstract Somatostatin signals through somatostatin receptor subtypes (SSTR) 2 and 5 to attenuate GH secretion. Although expressed in normal pituitary glands and in GH-secreting pituitary tumors, SSTR3 function was unclear, and we have now determined the role of SSTR3 in somatotroph function. Stable rat pituitary tumor cell (GC) transfectants of human SSTR3 (GpSSTR3WT) showed suppression of rat (r) GH promoter activity, GH mRNA...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968402
PubMed Central
by Lee, Seung-Pyo; Park, Sung-Ji; Kim, Yong-Jin; Chang, Sung-A; Park, Eun-Ah; Kim, Hyung-Kwan; Lee, Whal; Lee, Sang-Chol; Park, Seung Woo; Sohn, Dae-Won; Choe, Yeon-Hyeon
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This article is from Journal of Cardiovascular Magnetic Resonance , volume 15 . Abstract Background: Severe aortic stenosis (AS) patients with late gadolinium enhancement (LGE) on cardiovascular magnetic resonance (CMR) or left ventricular (LV) systolic dysfunction are known to have worse outcome. We aimed to investigate whether LGE on CMR would be useful in early detection of subclinical LV structural and functional derangements in AS patients. Methods: 118 patients with moderate to severe AS...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766067
PubMed Central
by Hong, Seung-Dok; Park, Seong-Hwan; Kang, Seung-Ji; Kwon, Yong Soo; Kee, Seung-Jung; Park, Kyung-Hwa; Jung, Sook-In; Jang, Hee-Chang
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This article is from Chonnam Medical Journal , volume 47 . Abstract It has been suggested that oseltamivir-resistant influenza viruses harboring the H274/275Y mutation are less virulent than are those that are oseltamivir-sensitive, and fatality attributed to infection with an oseltamivir-resistant virus is very rare. Here we report the first fatal adult case of oseltamivir-resistant 2009 pandemic influenza A (H1N1) in Korea. A 60-year-old Korean male who had hypertension, diabetes mellitus,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3214869
biorxiv
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I propose a method that estimates the selection response of all vital rates in an age-structured population. I assume that vital rates are determined by the additive genetic contributions of many loci. The method uses all relatedness information in the sample to inform its estimates of genetic parameters, via an MCMC Bayesian framework. One can use the results to estimate the selection response of any life history trait that is a function of the vital rates, including the age at first...
Topic: Evolutionary Biology
Source: http://biorxiv.org/content/early/2014/02/19/002584
biorxiv
by Katie Hinde; Abigail J Carpenter; John C Clay; Barry J Bradford
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Mammalian females pay high energetic costs for reproduction, the greatest of which is imposed by lactation. The synthesis of milk requires, in part, the mobilization of bodily reserves to nourish developing young. Numerous hypotheses have been advanced to predict how mothers will differentially invest in sons and daughters, however few studies have addressed sex-biased milk synthesis. Here we leverage the dairy cow model to investigate such phenomena. Using 2.39 million lactation records from...
Topic: Evolutionary Biology
Source: http://biorxiv.org/content/early/2014/01/24/002063
Arxiv.org
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We find the height of the third fission barrier $B_{III}$ and energy of the third minimum $E_{III}$ in $^{232}$Th using the macroscopic - microscopic model, very well tested in this region of nuclei. For the first time it is done on an 8-dimensional deformation hypercube. The dipole distortion is included among the shape variables to assure that no important shapes are missed. The saddle point is found on a lattice containing more than 50 million points by the immersion water flow (IWF) method....
Topic: Nuclear Theory
Source: http://arxiv.org/abs/1301.0713
PubMed Central
by Garimella, Rama; Washington, Laurie; Isaacson, Janalee; Vallejo, Julian; Spence, Madoka; Tawfik, Ossama; Rowe, Peter; Brotto, Marco; Perez, Raymond
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This article is from Translational Oncology , volume 7 . Abstract The bone microenvironment (BME) is the main hub of all skeletal related pathological events in osteosarcoma leading to tumor induced bone destruction, and decreasing overall bone quality and bone strength. The role of extra-cellular membrane vesicles (EMVs) as mediators of intercellular communication in modulating osteosarcoma-BME is unknown, and needs to be investigated. It is our hypothesis that osteosarcoma-EMVs contain...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145399
biorxiv
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Most evolving populations are subdivided into multiple subpopulations connected to each other by varying levels of gene flow. However, how population structure and gene flow (i.e., migration) affect adaptive evolution is not well understood. Here, we studied the impact of migration on asexually reproducing evolving computer programs (digital organisms). We found that digital organisms evolve the highest fitness values at intermediate migration rates, and we tested three hypotheses that could...
Topic: Evolutionary Biology
Source: http://biorxiv.org/content/early/2014/04/04/003897
PubMed Central
by Michael, Iacovos P; Westenskow, Peter D; Hacibekiroglu, Sabiha; Greenwald, Alissa Cohen; Ballios, Brian G; Kurihara, Toshihide; Li, Zhijie; Warren, Carmen M; Zhang, Puzheng; Aguilar, Edith; Donaldson, Laura; Marchetti, Valentina; Baba, Takeshi; Hussein, Samer M; Sung, Hoon-Ki; Iruela-Arispe, M Luisa; Rini, James M; van der Kooy, Derek; Friedlander, Martin; Nagy, Andras
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This article is from EMBO Molecular Medicine , volume 6 . Abstract Current therapeutic antiangiogenic biologics used for the treatment of pathological ocular angiogenesis could have serious side effects due to their interference with normal blood vessel physiology. Here, we report the generation of novel antivascular endothelial growth factor-A (VEGF) biologics, termed VEGF “Sticky-traps,” with unique properties that allow for local inhibition of angiogenesis without detectable systemic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023884
PubMed Central
by Sanz-Pamplona, Rebeca; Berenguer, Antoni; Cordero, David; Mollevi, David G; Crous-Bou, Marta; Sole, Xavier; Pare-Brunet, Laia; Guino, Elisabet; Salazar, Ramon; Santos, Cristina; de Oca, Javier; Sanjuan, Xavier; Rodriguez-Moranta, Francisco; Moreno, Victor
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This article is from Molecular Cancer , volume 13 . Abstract Background: A colorectal tumor is not an isolated entity growing in a restricted location of the body. The patient’s gut environment constitutes the framework where the tumor evolves and this relationship promotes and includes a complex and tight correlation of the tumor with inflammation, blood vessels formation, nutrition, and gut microbiome composition. The tumor influence in the environment could both promote an anti-tumor or a...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023701
PubMed Central
by Andonaba, Jean Baptiste; Barro-Traore, Fatou; Korsaga, Some; Diallo, Boukary; Diallo, Jean Wilfried; Traore, Adama
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This article is from The Pan African Medical Journal , volume 16 . Abstract Le pseudoxanthome élastique (PXE) est une maladie héréditaire du tissu élastique affectant principalement la peau, les yeux et les artères. Nous rapportons une forme évolutive compliquée pour souligner la nécessité de la précocité du diagnostic et du suivi, de l'approche multidisciplinaire et la prise en charge des complications. Une femme de 51 ans, a consulté pour des nappes fripées de papules typiquement...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024434
PubMed Central
by O'Brien, Travis J; Harralson, Arthur F; Tran, Tuyen; Gindoff, Ian; Orkunoglu-Suer, Funda E; Frankfurter, David; Gindoff, Paul
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This article is from Reproductive Biology and Endocrinology : RB&E , volume 12 . Abstract Background: The objective of this investigation was to determine if kinase insert domain/vascular endothelial growth factor receptor 2 (KDR/VEGFR2) genetic variation was associated with the development of ovarian hyperstimulation syndrome (OHSS) in patients undergoing controlled ovarian hyperstimulation (COH). Methods: This was a case–control study of 174 patients who underwent controlled ovarian...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024119
PubMed Central
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This article is from SpringerPlus , volume 3 . Abstract This study aims at critically assessing the land management strategies that can be instrumental in bringing sound governance to urban landscapes in Africa with the view of mapping the potential, minimum conditions for success and constraints to doing so. This study is qualitative by approach and case study based by design, assesses practices in land management from a few cities (Nairobi, Abuja, Harare, Kigali, Johannesburg and Addis...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024482
PubMed Central
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This article is from BMJ Open , volume 4 . Abstract Objectives: To explore the experiences of oncology staff with communicating safety concerns and to examine situational factors and motivations surrounding the decision whether and how to speak up using semistructured interviews. Setting: 7 oncology departments of six hospitals in Switzerland. Participants: Diverse sample of 32 experienced oncology healthcare professionals. Results: Nurses and doctors commonly experience situations which raise...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025461
PubMed Central
by Ahmed, Shoeb; Grant, Kyle G; Edwards, Laura E; Rahman, Anisur; Cirit, Murat; Goshe, Michael B; Haugh, Jason M
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This article is from Molecular Systems Biology , volume 10 . Abstract The extracellular signal‐regulated kinase (ERK) signaling pathway controls cell proliferation and differentiation in metazoans. Two hallmarks of its dynamics are adaptation of ERK phosphorylation, which has been linked to negative feedback, and nucleocytoplasmic shuttling, which allows active ERK to phosphorylate protein substrates in the nucleus and cytosol. To integrate these complex features, we acquired quantitative...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023404
PubMed Central
by Kim, Hochang; Park, Jongyeop; Jang, Jaeho; Chun, Junwoo
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This article is from The Journal of Craniofacial Surgery , volume 25 . Abstract We describe an infant with respiratory distress due to bilateral dacryocystoceles and dacryocystitis who was successfully treated with urgent bilateral endoscopic marsupialization.A male infant was brought to our outpatient department 7 days after birth, with red, acutely inflamed swellings near the medial canthal area of both eyes. From birth, there had been bluish swelling near the medial canthal area, and redness...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025628
PubMed Central
by Chen, Yun-An; Chi, Wen-Chang; Trinh, Ngoc Nam; Huang, Li-Yao; Chen, Ying-Chih; Cheng, Kai-Teng; Huang, Tsai-Lien; Lin, Chung-Yi; Huang, Hao-Jen
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This article is from PLoS ONE , volume 9 . Abstract Mercury (Hg) is a serious environmental pollution threat to the planet. The accumulation of Hg in plants disrupts many cellular-level functions and inhibits growth and development, but the mechanism is not fully understood. To gain more insight into the cellular response to Hg, we performed a large-scale analysis of the rice transcriptome during Hg stress. Genes induced with short-term exposure represented functional categories of cell-wall...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026224
PubMed Central
by Huang, Yong; Zhang, Xiujuan; Du, Qian; Wang, Fengyu; Zhao, Xiaomin; Zhang, Wenlong; Tong, Dewen
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This article is from PLoS ONE , volume 9 . Abstract Porcine circovirus type 2 (PCV2) has emerged as one of the most important pathogens affecting swine production globally. Preclinical identification of PCV2 is very important for effective prophylaxis of PCV2-associated diseases. In this study, we developed an ultrasensitive nanoparticle DNA probe-based PCR assay (UNDP-PCR) for PCV2 detection. Magnetic microparticles coated with PCV2 specific DNA probes were used to enrich PCV2 DNA from...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026479
PubMed Central
by Sigl, Reinhard; Ploner, Christian; Shivalingaiah, Giridhar; Kofler, Reinhard; Geley, Stephan
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This article is from PLoS ONE , volume 9 . Abstract RNA interference (RNAi) has become an essential technology for functional gene analysis. Its success, however, depends on the effective expression of RNAi-inducing small double-stranded interfering RNA molecules (siRNAs) in target cells. In many cell types, RNAi can be achieved by transfection of chemically synthesised siRNAs, which results in transient knockdown of protein expression. Expression of double-stranded short hairpin RNA (shRNA)...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026376
PubMed Central
by Jackson, Doug; Vandermeer, John; Perfecto, Ivette; Philpott, Stacy M.
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This article is from PLoS ONE , volume 9 . Abstract Spatial structure can have a profound, but often underappreciated, effect on the temporal dynamics of ecosystems. Here we report on a counterintuitive increase in the population of a tree-nesting ant, Azteca sericeasur, in response to a drastic reduction in the number of potential nesting sites. This surprising result is comprehensible when viewed in the context of the self-organized spatial dynamics of the ants and their effect on the ants’...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026481
PubMed Central
by Kim, Ae Ryoung; Chang, Jin Woo; Chang, Won Seok; Park, Eun Sook; Cho, Sung-Rae
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This article is from Annals of Rehabilitation Medicine , volume 38 . Abstract Objective: To investigate the effect of deep brain stimulation (DBS) on reducing dystonia and disability in adults with cerebral palsy (CP) and to compare the therapeutic outcomes between primary dystonia patients and CP patients over two years after bilateral pallidal DBS. Methods: Five patients with primary dystonia and seven CP patients with dystonia were recruited. All subjects received DBS surgery in both globus...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026607
PubMed Central
by Ale, OK; Ajuluchukwu, JN; Oke, DA; Mbakwem, AC
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This article is from Cardiovascular Journal of Africa , volume 25 . Abstract Background: Prehypertension has been associated with target-organ damage. This study sought to determine the impact of prehypertension (PHT) on QT dispersion and left ventricular hypertrophy (LVH) in adult black Nigerians. Methods: One hundred and one subjects with office blood pressure (BP) < 140/90 mmHg were categorised according to their office BP into normotensive (BP < 120/80 mmHg, n = 57) and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026767
PubMed Central
by Silva, Anjana; Marikar, Faiz; Murugananthan, Arumugam; Agampodi, Suneth
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This article is from Journal of Occupational Medicine and Toxicology (London, England) , volume 9 . Abstract Background: Snakebite is a global health problem associated with high morbidity and mortality. In Sri Lanka, snakebite is mainly an occupational health hazard associated with farming. Understanding awareness and perceptions in risk populations on the preventive measures, first aid and treatment for snakebite becomes pivotal in designing snakebite prevention and control programs. Using an...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026859
PubMed Central
by Kim, Young Deok; Park, Jae Hyun; Yang, Seung-Ho; Kim, Il Sup; Hong, Jae Taek; Sung, Jae Hoon; Son, Byung Chul; Lee, Sang Won
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This article is from Brain Tumor Research and Treatment , volume 1 . Abstract Objective: This study was performed to assess the postoperative pain of brain tumor patients who underwent elective craniotomy and to evaluate the factors associated with pain intensity. Methods: From January 2010 to December 2011, 47 patients with newly diagnosed brain tumors who underwent craniotomy were enrolled. The postoperative pain status was assessed daily until discharge using the visual analogue scale (VAS)....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027119
PubMed Central
by Zhao, Chao; Wang, Hailin; Zhao, Bailin; Li, Cuiping; Yin, Ruichuan; Song, Maoyong; Liu, Baodong; Liu, Zhen; Jiang, Guibin
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This article is from Nucleic Acids Research , volume 42 . Abstract The gene- or fragment-specific detection of newly recognized deoxyribonucleic acid (DNA) base 5-hydroxymethylcytosine (5hmC) will provide insights into its critical functions in development and diseases, and is also important for screening 5hmC-rich genes as an indicator of epigenetic states, pathogenic processes and pharmacological responses. Current analytical technologies for gene-specific detection of 5hmC are heavily...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027215
PubMed Central
by Maslon, Magdalena M; Heras, Sara R; Bellora, Nicolas; Eyras, Eduardo; Caceres, Javier F
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This article is from eLife , volume 3 . Abstract The shuttling serine/arginine rich (SR) protein SRSF1 (previously known as SF2/ASF) is a splicing regulator that also activates translation in the cytoplasm. In order to dissect the gene network that is translationally regulated by SRSF1, we performed a high-throughput deep sequencing analysis of polysomal fractions in cells overexpressing SRSF1. We identified approximately 1500 mRNAs that are translational targets of SRSF1. These include mRNAs...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027812
This article is from Journal of Movement Disorders , volume 5 . Abstract Background and Purpose:: Multiple system atrophy with predominant cerebellar ataxia is a disabling neurologic disease. However, effective management has not yet been established. We conducted a short-term, open-label preliminary study to assess the benefits of intravenous amantadine treatment in patients with probable multiple system atrophy with predominant cerebellar ataxia. Methods:: Twenty patients (10 male, 10 female)...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027678
PubMed Central
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This article is from The Journal of Physiology , volume 592 . Abstract Hair cells detect and process sound and movement information, and transmit this with remarkable precision and efficiency to afferent neurons via specialized ribbon synapses. The zebrafish is emerging as a powerful model for genetic analysis of hair cell development and function both in vitro and in vivo. However, the full exploitation of the zebrafish is currently limited by the difficulty in obtaining systematic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027864
PubMed Central
by Kargulewicz, Angelika; Stankowiak-Kulpa, Hanna; Grzymislawski, Marian
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This article is from Przegla̜d Gastroenterologiczny , volume 9 . Abstract Changes to patients’ lifestyle, especially a modified dietary approach, play a key role in the treatment of nonalcoholic fatty liver disease (NAFLD). A balanced, limiting and individually tailored nutritional scheme enables weight loss and an improvement in the clinical picture of NAFLD. According to nutritional recommendations for patients with NAFLD, carbohydrates should comprise 40–50% of total dietary energy. It...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027841
PubMed Central
by Al-Hashel, Jasem Y; Ahmed, Samar Farouk; Alroughani, Raed; Goadsby, Peter J
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This article is from The Journal of Headache and Pain , volume 14 . Abstract Background: Sinusitis is the most frequent misdiagnosis given to patients with migraine.Therefore we decided to estimate the frequency of misdiagnosis of sinusitis among migraine patients. Methods: The study included migraine patients with a past history of sinusitis. All included cases fulfilled the International Classification of Headache Disorders, 3rd edition (ICHD-III- beta) criteria. We excluded patients with...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028747
PubMed Central
by Du, Wenjun; Zhen, Junhui; Zheng, Zhaomin; Ma, Shumin; Chen, Shijun
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This article is from Journal of Inflammation (London, England) , volume 10 . Abstract Background & aims: Innate immunity is the first line of defense against invasive microbial infection, and AIM2 plays an important role in this process by sensing double-stranded DNA viruses. However, the role of AIM2 in regulating the immune response to viruses in vivo, especially in sensing hepatitis B virus (HBV), has not been examined. We hypothesized that the expression of AIM2 increases corresponding...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028891
PubMed Central
by Eriksson, Anna-Karin; Lofving, Sofia; Callaghan, Russell C; Allebeck, Peter
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This article is from BMC Neurology , volume 13 . Abstract Background: Alcohol has been suggested to be either protective of, or not associated with Parkinson’s disease (PD). However, experimental animal studies indicate that chronic heavy alcohol consumption may have dopamine neurotoxic effects relevant for PD. We studied the association between diagnosed alcohol use disorders and PD. Methods: All individuals in Sweden admitted with a diagnosis of an alcohol use disorder or appendicitis...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029307
PubMed Central
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This article is from Sensors (Basel, Switzerland) , volume 14 . Abstract Dempster-Shafer evidence theory (DSET) is a flexible and popular paradigm for multisource data fusion in wireless sensor networks (WSNs). This paper presents a novel and easy implementing method computing masses from the hundreds of pieces of data collected by a WSN. The transfer model is based on the Mahalanobis distance (MD), which is an effective method to measure the similarity between an object and a sample. Compared...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029685
PubMed Central
by Coste, Christine Azevedo; Sijobert, Benoit; Pissard-Gibollet, Roger; Pasquier, Maud; Espiau, Bernard; Geny, Christian
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This article is from Sensors (Basel, Switzerland) , volume 14 . Abstract Freezing of gait (FOG) is a common symptom in Parkinsonism, which affects the gait pattern and is associated to a fall risk. Automatized FOG episode detection would allow systematic assessment of patient state and objective evaluation of the clinical effects of treatments. Techniques have been proposed in the literature to identify FOG episodes based on the frequency properties of inertial sensor signals. Our objective...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029660
PubMed Central
by Brantner, Justin S.; Haake, Zachary J.; Burwick, John E.; Menge, Christopher M.; Hotchkiss, Shane T.; Senko, John M.
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This article is from Frontiers in Microbiology , volume 5 . Abstract We evaluated the depth-dependent geochemistry and microbiology of sediments that have developed via the microbially-mediated oxidation of Fe(II) dissolved in acid mine drainage (AMD), giving rise to a 8–10 cm deep “iron mound” that is composed primarily of Fe(III) (hydr)oxide phases. Chemical analyses of iron mound sediments indicated a zone of maximal Fe(III) reducing bacterial activity at a depth of approximately 2.5...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030175
PubMed Central
by Aguirre, Enara; Renner, Oliver; Narlik-Grassow, Maja; Blanco-Aparicio, Carmen
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This article is from Frontiers in Oncology , volume 4 . Abstract The PIM proteins, which were initially discovered as proviral insertion sites in Moloney-murine leukemia virus infection, are a family of highly homologous serine/threonine kinases that have been reported to be overexpressed in hematological malignancies and solid tumors. The PIM proteins have also been associated with metastasis and overall treatment responses and implicated in the regulation of apoptosis, metabolism, the cell...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030178
PubMed Central
by Bornelov, Susanne; Marillet, Simon; Komorowski, Jan
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This article is from BMC Bioinformatics , volume 15 . Abstract Background: The use of classification algorithms is becoming increasingly important for the field of computational biology. However, not only the quality of the classification, but also its biological interpretation is important. This interpretation may be eased if interacting elements can be identified and visualized, something that requires appropriate tools and methods. Results: We developed a new approach to detecting...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030460
PubMed Central
by Hsu, Joanne H.; Weier, Jingly F.; Weier, Heinz-Ulrich G.; Ito, Yuko
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This article is from Biomolecules , volume 3 . Abstract Many human tumors show significant changes in their signal transduction pathways and, thus, the way the cells interact with their environment. Often caused by chromosomal rearrangements, including gene amplifications, translocations or deletions, the altered levels of gene expression may provide a tumor-specific signature that can be exploited for diagnostic or therapeutic purposes. We investigated the utility of multiplexed fluorescence...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030878
PubMed Central
by Morikawa, Masayuki; Kino, Katsuhito; Oyoshi, Takanori; Suzuki, Masayo; Kobayashi, Takanobu; Miyazawa, Hiroshi
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This article is from Biomolecules , volume 4 . Abstract Guanine is the most easily oxidized among the four DNA bases, and some guanine-rich sequences can form quadruplex structures. In a previous study using 6-mer DNA d(TGGGGT), which is the shortest oligomer capable of forming quadruplex structures, we demonstrated that guanine oxidation products of quadruplex DNA differ from those of single-stranded DNA. Therefore, the hotooxidation products of double-stranded DNA (dsDNA) may also differ from...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030987
PubMed Central
by Wang, Hongxuan; Tang, Yamei; Rong, Xiaoming; Li, Hui; Pan, Rui; Wang, Yidong; Peng, Ying
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This article is from PLoS ONE , volume 9 . Abstract Background: Hypertension is common after acute stroke onset. Previous studies showed controversial effects of early blood pressure (BP) lowering on stroke outcomes. The aim of this study is to assess the effects of early BP lowering on early and long-term outcomes after acute stroke. Methods: A meta-analysis was conducted with prospective randomized controlled trials assessing the effects of early BP lowering on early and long-term outcomes...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031127
PubMed Central
by Trochine, Andrea; Creek, Darren J.; Faral-Tello, Paula; Barrett, Michael P.; Robello, Carlos
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This article is from PLoS Neglected Tropical Diseases , volume 8 . Abstract Background: The first line treatment for Chagas disease, a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi, involves administration of benznidazole (Bzn). Bzn is a 2-nitroimidazole pro-drug which requires nitroreduction to become active, although its mode of action is not fully understood. In the present work we used a non-targeted MS-based metabolomics approach to study the metabolic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031082
PubMed Central
by de la Fuente-Nunez, Cesar; Reffuveille, Fany; Haney, Evan F.; Straus, Suzana K.; Hancock, Robert E. W.
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This article is from PLoS Pathogens , volume 10 . Abstract Bacteria form multicellular communities known as biofilms that cause two thirds of all infections and demonstrate a 10 to 1000 fold increase in adaptive resistance to conventional antibiotics. Currently, there are no approved drugs that specifically target bacterial biofilms. Here we identified a potent anti-biofilm peptide 1018 that worked by blocking (p)ppGpp, an important signal in biofilm development. At concentrations that did not...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031209
PubMed Central
by Campassi, Maria Luz; Gonzalez, Maria Cecilia; Masevicius, Fabio Daniel; Vazquez, Alejandro Risso; Moseinco, Miriam; Navarro, Noelia Cintia; Previgliano, Luciana; Rubatto, Nahuel Paolo; Benites, Martin Hernan; Estenssoro, Elisa; Dubin, Arnaldo
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This article is from Revista Brasileira de Terapia Intensiva , volume 26 . Abstract Objective: An augmented renal clearance has been described in some groups of critically ill patients, and it might induce sub-optimal concentrations of drugs eliminated by glomerular filtration, mainly antibiotics. Studies on its occurrence and determinants are lacking. Our goals were to determine the incidence and associated factors of augmented renal clearance and the effects on vancomycin concentrations and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031886
PubMed Central
by Rafiee, Mohammad; Jahangiri-rad, Mahsa; Hajjaran, Homa; Mesdaghinia, Alireza; Hajaghazadeh, Mohammad
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This article is from Journal of Environmental Health Science and Engineering , volume 12 . Abstract Legionella spp. are important waterborne pathogens that are normally transmitted through aerosols. The present work was conducted to investigate the presence of Legionella spp. and its common species in hospital water supplies. Considering the limitations of culture method, polymerase chain reaction (PCR) assays were developed to detect the gene 16S rRNA irrespective of the bacterial serotype....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032159
PubMed Central
by Breman, Eytan; van Miert, Paula P.; van der Steen, Dirk M.; Heemskerk, Mirjam H.; Doxiadis, Ilias I.; Roelen, Dave; Claas, Frans H.; van Kooten, Cees
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This article is from Transplantation , volume 97 . Abstract Background: Recognition of donor antigens can occur through two separate pathways: the direct pathway (non-self HLA on donor cells) and the indirect pathway (self-restricted presentation of donor derived peptides on recipient cells). Indirect allorecognition is important in the development of humoral rejection; therefore, there is an increasing interest in the monitoring of indirect alloreactive T-cells. We have used an in vitro model...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032218
PubMed Central
by Palmer, Liisa; White, Ronald R.; Johnson, Barbara H.; Fowler, Robert; Acosta, Camilo J.
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This article is from Transplantation , volume 97 . Abstract Objectives: To evaluate health-care utilization and costs attributable to herpes zoster (HZ) within a population of patients with solid organ transplant (SOT). Methods: Using administrative claims data, a commercially/Medicare-insured population of patients with SOT between January 1, 1999, and January 1, 2007, and a Medicaid population between January 1, 1999, and January 1, 2006, were identified. Each patient group was screened to...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032219
PubMed Central
by Parris, Toshima Z; Aziz, Luaay; Kovacs, Aniko; Hajizadeh, Shahin; Nemes, Szilard; Semaan, May; Chen, Chang Yan; Karlsson, Per; Helou, Khalil
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This article is from BMC Cancer , volume 14 . Abstract Background: Squamous cell carcinoma of the oral cavity (OSCC) is a common cancer form with relatively low 5-year survival rates, due partially to late detection and lack of complementary molecular markers as targets for treatment. Molecular profiling of head and neck cancer has revealed biological similarities with basal-like breast and lung carcinoma. Recently, we showed that 16 genes were consistently altered in invasive breast tumors...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031971
PubMed Central
by Taha, Hana; Nystrom, Lennarth; Al-Qutob, Raeda; Berggren, Vanja; Esmaily, Hamideh; Wahlstrom, Rolf
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This article is from BMC Public Health , volume 14 . Abstract Background: Breast cancer is the most common cancer afflicting women in Jordan. This study aimed to assess the effects of an educational intervention through home visits, including offering free mammography screening vouchers, on changing women’s breast health knowledge and screening practices for early detection of breast cancer in a less privileged area in Jordan. Methods: Two thousand four hundred breast health awareness home...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031932
PubMed Central
by Marshall, Patricia A; Adebamowo, Clement A; Adeyemo, Adebowale A; Ogundiran, Temidayo O; Strenski, Teri; Zhou, Jie; Rotimi, Charles N
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This article is from BMC Medical Ethics , volume 15 . Abstract Background: Studies on informed consent to medical research conducted in low or middle-income settings have increased, including empirical investigations of consent to genetic research. We investigated voluntary participation and comprehension of informed consent among women involved in a genetic epidemiological study on breast cancer in an urban setting of Nigeria comparing women in the case and control groups. Methods: Surveys...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032563
PubMed Central
by Olsen, Dana; J?rgensen, Jan Tr?st
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This article is from Frontiers in Oncology , volume 4 . Abstract Companion diagnostics (CDx) holds the promise of improving the predictability of the oncology drug development process and become an important tool for the oncologist in relation to the choice of treatment for the individual patient. A number of drug–diagnostic co-development programs have already been completed successfully, and in the clinic, the use of several targeted cancer drugs is now guided by a CDx. This central role of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032883
PubMed Central
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This article is from Journal of Reproduction & Infertility , volume 15 . Abstract Background: Sacrococcygeal teratoma (SCT) is a rare congenital tumor and its association with IVF pregnancy is not clear. There are limited reports of congenital tumors in IVF pregnancy. The exact embryogenesis of SCT is not known but a genetic etiology has been reported. Whether these congenital tumors have any association with assisted reproductive techniques remains obscure. Case Presentation: In this...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032967
PubMed Central
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This article is from Biology of Sport , volume 29 . Abstract The purpose of this paper was: a) to provide reference values for the standing spike test for female volleyball players and b) to study whether the standing spike test is valid for assessing the theoretical differences between female volleyball players. The sample included 83 players from the first nine teams of the Spanish women's first volleyball division (52 Spanish players and 31 from other nationalities). The variables studied...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033062
PubMed Central
by Giretti, Maria Silvia; Montt Guevara, Maria Magdalena; Cecchi, Elena; Mannella, Paolo; Palla, Giulia; Spina, Stefania; Bernacchi, Guja; Di Bello, Silvia; Genazzani, Andrea Riccardo; Genazzani, Alessandro D.; Simoncini, Tommaso
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This article is from Frontiers in Endocrinology , volume 5 . Abstract Estetrol (E4) is a natural human estrogen present at high concentrations during pregnancy. Due to its high oral bioavailability and long plasma half-life, E4 is particularly suitable for therapeutic applications. E4 acts as a selective estrogen receptor (ER) modulator, exerting estrogenic actions on the endometrium or the central nervous system, while antagonizing the actions of estradiol in the breast. We tested the effects...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033260
PubMed Central
by Janssen, Joseph A. M. J. L.; Varewijck, Aimee J.
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This article is from Frontiers in Endocrinology , volume 5 . Abstract In view of the lifelong exposure and large patient populations involved, insulin analogs with an increased mitogenic effect in comparison to human insulin may potentially constitute a major health problem, since these analogs may possibly induce the growth of pre-existing neoplasms. At present, the available data suggest that insulin analogs are safe. In line with these findings, we observed that serum of diabetic patients...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033362
This article is from Frontiers in Neural Circuits , volume 8 . Abstract Cognitive functions associated with prefrontal cortex (PFC), such as working memory and attention, are strongly influenced by catecholamine [dopamine (DA) and norepinephrine (NE)] release. Midbrain dopaminergic neurons in the ventral tegmental area and noradrenergic neurons in the locus coeruleus are major sources of DA and NE to the PFC. It is traditionally believed that DA and NE neurons are homogeneous with highly...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033238
PubMed Central
by Krause, Sascha; Le Roux, Xavier; Niklaus, Pascal A.; Van Bodegom, Peter M.; Lennon, Jay T.; Bertilsson, Stefan; Grossart, Hans-Peter; Philippot, Laurent; Bodelier, Paul L. E.
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This article is from Frontiers in Microbiology , volume 5 . Abstract In ecology, biodiversity-ecosystem functioning (BEF) research has seen a shift in perspective from taxonomy to function in the last two decades, with successful application of trait-based approaches. This shift offers opportunities for a deeper mechanistic understanding of the role of biodiversity in maintaining multiple ecosystem processes and services. In this paper, we highlight studies that have focused on BEF of microbial...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033906
PubMed Central
by Compare, Debora; Nardone, Olga; Nardone, Gerardo
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This article is from Pharmaceuticals , volume 3 . Abstract It is estimated that underlying infections and inflammatory responses are linked to 15–20% of all deaths from cancer worldwide. Inflammation is a physiologic process in response to tissue damage resulting from microbial pathogen infection, chemical irritation, and/or wounding. Tissues injured throughout the recruitment of inflammatory cells such as macrophages and neutrophils, generate a great amount of growth factors, cytokines, and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033936
PubMed Central
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This article is from Pharmaceuticals , volume 3 . Abstract Bacterial infections are common in the neonates and are a major cause of morbidity and mortality. Sixty percent of preterm infants admitted to neonatal intensive care units received at least one antibiotic during the first week of life. Penicillins, aminoglycosides and cephalosporins comprised 53, 43 and 16%, respectively. Kinetic parameters such as the half-life (t1/2), clearance (Cl), and volume of distribution (Vd) change with...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033939
PubMed Central
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This article is from Pharmaceuticals , volume 3 . Abstract Affective disorders represent the most common psychiatric diseases, with substantial co-morbidity existing between major depressive disorders (MDD) and anxiety disorders. The lack of truly novel acting compounds has led to non-monoaminergic based research and hypotheses in recent years. The large number of brain neuropeptides, characterized by discrete synthesis sites and multiple receptors, represent likely research candidates for...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033976
PubMed Central
by Ferraldeschi, Roberta; Newman, William G.
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This article is from Pharmaceuticals , volume 3 . Abstract Tamoxifen remains a cornerstone of treatment for patients with oestrogen-receptor-positive breast cancer. Tamoxifen efficacy depends on the biotransformation, predominantly via the cytochrome P450 2D6 (CYP2D6) isoform, to the active metabolite endoxifen. Both genetic and environmental (drug-induced) factors may alter CYP2D6 enzyme activity directly affecting the concentrations of active tamoxifen metabolites. Several studies suggest...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034025
PubMed Central
by Waye, Mary Miu Yee; Sing, Chor Wing
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This article is from Pharmaceuticals , volume 3 . Abstract There are many stages in the development of a new drug for viral infection and such processes are even further complicated for adenovirus by the fact that there are at least 51 serotypes, forming six distinct groups (A–F), with different degree of infectivity. This review attempts to address the importance of developing pharmaceuticals for adenovirus and also review recent development in drug discovery for adenovirus, including newer...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034094
PubMed Central
by Kwon, Young-Ju; Park, Mi-Jeong; Kim, Sang-Gyu; Baldwin, Ian T; Park, Chung-Mo
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This article is from BMC Plant Biology , volume 14 . Abstract Background: The circadian clock enables living organisms to anticipate recurring daily and seasonal fluctuations in their growth habitats and synchronize their biology to the environmental cycle. The plant circadian clock consists of multiple transcription-translation feedback loops that are entrained by environmental signals, such as light and temperature. In recent years, alternative splicing emerges as an important molecular...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035800
PubMed Central
by Wang, Wen-Zhao; Morohoshi, Tomohiro; Someya, Nobutaka; Ikeda, Tsukasa
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This article is from Microbes and Environments , volume 27 . Abstract N-Acylhomoserine lactone (AHL)-degrading enzyme, AiiM, was identified from the potato leaf-associated Microbacterium testaceum StLB037. In this study, we cloned eight aiiM gene homologues from other AHL-degrading Microbacterium strains. The similarity of the chromosomal locus of the aiiM gene is associated with the phylogenetic classification based on 16S rRNA. Degenerate PCR revealed that the aiiM gene was only conserved in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036043
PubMed Central
by Chubukov, Victor; Uhr, Markus; Le Chat, Ludovic; Kleijn, Roelco J; Jules, Matthieu; Link, Hannes; Aymerich, Stephane; Stelling, Jorg; Sauer, Uwe
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This article is from Molecular Systems Biology , volume 9 . Abstract Regulation of enzyme expression is one key mechanism by which cells control their metabolic programs. In this work, a quantitative analysis of metabolism in a model bacterium under different conditions shows that expression alone cannot explain the majority of the observed metabolic changes.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039378
PubMed Central
by van Hooff, Jolien J.E.; Snel, Berend; Seidl, Michael F.
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This article is from Genome Biology and Evolution , volume 6 . Abstract Genomes of the plant-pathogenic genus Phytophthora are characterized by small duplicated blocks consisting of two consecutive genes (2HOM blocks) and by an elevated abundance of similarly aged gene duplicates. Both properties, in particular the presence of 2HOM blocks, have been attributed to a whole-genome duplication (WGD) at the last common ancestor of Phytophthora. However, large intraspecies synteny—compelling...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040989
PubMed Central
by von Hacht, Annekathrin; Seifert, Oliver; Menger, Marcus; Schutze, Tatjana; Arora, Amit; Konthur, Zoltan; Neubauer, Peter; Wagner, Anke; Weise, Christoph; Kurreck, Jens
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This article is from Nucleic Acids Research , volume 42 . Abstract Guanine quadruplex (G-quadruplex) motifs in the 5′ untranslated region (5′-UTR) of mRNAs were recently shown to influence the efficiency of translation. In the present study, we investigate the interaction between cellular proteins and the G-quadruplexes located in two mRNAs (MMP16 and ARPC2). Formation of the G-quadruplexes was confirmed by biophysical characterization and the inhibitory activity on translation was shown by...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041461
PubMed Central
by Donat, Ulrike; Rother, Juliane; Schafer, Simon; Hess, Michael; Hartl, Barbara; Kober, Christina; Langbein-Laugwitz, Johanna; Stritzker, Jochen; Chen, Nanhai G.; Aguilar, Richard J.; Weibel, Stephanie; Szalay, Aladar A.
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This article is from PLoS ONE , volume 9 . Abstract More than 90% of cancer mortalities are due to cancer that has metastasized. Therefore, it is crucial to intensify research on metastasis formation and therapy. Here, we describe for the first time the metastasizing ability of the human cervical cancer cell line C33A in athymic nude mice after subcutaneous implantation of tumor cells. In this model, we demonstrated a steady progression of lumbar and renal lymph node metastases during tumor...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041767
PubMed Central
by Ali, Hazrat; Ries, Marco I.; Lankhorst, Peter P.; van der Hoeven, Rob A. M.; Schouten, Olaf L.; Noga, Marek; Hankemeier, Thomas; van Peij, Noel N. M. E.; Bovenberg, Roel A. L.; Vreeken, Rob J.; Driessen, Arnold J. M.
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This article is from PLoS ONE , volume 9 . Abstract The filamentous fungus Penicillium chrysogenum harbors an astonishing variety of nonribosomal peptide synthetase genes, which encode proteins known to produce complex bioactive metabolites from simple building blocks. Here we report a novel non-canonical tetra-modular nonribosomal peptide synthetase (NRPS) with microheterogenicity of all involved adenylation domains towards their respective substrates. By deleting the putative gene in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041764
PubMed Central
by Bertin, Yolande; Deval, Christiane; de la Foye, Anne; Masson, Luke; Gannon, Victor; Harel, Josee; Martin, Christine; Desvaux, Mickael; Forano, Evelyne
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This article is from PLoS ONE , volume 9 . Abstract Enterohaemorrhagic Escherichia coli (EHEC) are responsible for outbreaks of food- and water-borne illness. The bovine gastrointestinal tract (GIT) is thought to be the principle reservoir of EHEC. Knowledge of the nutrients essential for EHEC growth and survival in the bovine intestine may help in developing strategies to limit their shedding in bovine faeces thus reducing the risk of human illnesses. To identify specific metabolic pathways...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041753
PubMed Central
by van der Zwan, Yvonne G.; Rijlaarsdam, Martin A.; Rossello, Fernando J.; Notini, Amanda J.; de Boer, Suzan; Watkins, D. Neil; Gillis, Ad J. M.; Dorssers, Lambert C. J.; White, Stefan J.; Looijenga, Leendert H. J.
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This article is from PLoS ONE , volume 9 . Abstract Background: Originating from Primordial Germ Cells/gonocytes and developing via a precursor lesion called Carcinoma In Situ (CIS), Germ Cell Cancers (GCC) are the most common cancer in young men, subdivided in seminoma (SE) and non-seminoma (NS). During physiological germ cell formation/maturation, epigenetic processes guard homeostasis by regulating the accessibility of the DNA to facilitate transcription. Epigenetic deregulation through...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041891
PubMed Central
by Chung, Hyun Sik
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This article is from Korean Journal of Anesthesiology , volume 66 . Abstract Anesthesia awareness is defined as both consciousness and recall of surgical events. New research has been conducted out to test this phenomenon. However, testing methods have not proven reliable, including those using devices based on electroencephalographic techniques to detect and prevent intraoperative awareness. The limitations of a standard intraoperative brain monitor reflect our insufficient understanding of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041951
PubMed Central
by Fujii, Kumiko; Ozeki, Yuji; Okayasu, Hiroaki; Takano, Yumiko; Shinozaki, Takahiro; Hori, Hiroaki; Orui, Masami; Horie, Minoru; Kunugi, Hiroshi; Shimoda, Kazutaka
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This article is from PLoS ONE , volume 9 . Abstract The potassium voltage-gated channel KCNH2 is a well-known gene in which mutations induce familial QT interval prolongation. KCNH2 is suggested to be a risk gene for schizophrenia. Additionally, the disturbance of autonomic control, which affects the QT interval, is known in schizophrenia. Therefore, we speculate that schizophrenic patients have characteristic features in terms of the QT interval in addition to the effect of antipsychotic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041785
This article is from Archives of Medical Science : AMS , volume 10 . Abstract Introduction: Vascular endothelial growth factor (VEGF) is overexpressed in pancreatic cancer. Although VEGF has been shown to be a probable marker for poor prognosis, the VEGF concentration in portal blood has not yet been clinically reported in pancreatic ductal adenocarcinoma (PDAC). The aim of the study was to measure VEGF-A portal blood concentration in patients with PDAC and to evaluate its performance as a...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042049
PubMed Central
by Pagliari, Stefania; Tirella, Annalisa; Ahluwalia, Arti; Duim, Sjoerd; Goumans, Marie-Jose; Aoyagi, Takao; Forte, Giancarlo
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This article is from Frontiers in Physiology , volume 5 . Abstract The vascularization of tissue engineered products represents a key issue in regenerative medicine which needs to be addressed before the translation of these protocols to the bedside can be foreseen. Here we propose a multistep procedure to prepare pre-vascularized three-dimensional (3D) cardiac bio-substitutes using dynamic cell cultures and highly porous biocompatible gelatin scaffolds. The strategy adopted exploits the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042082
PubMed Central
by Bratis, Konstantinos; Chiribiri, Amedeo; Hussain, Tarique; Krasemann, Thomas; Henningsson, Markus; Phinikaridou, Alkystis; Botnar, Rene; Mavrogeni, Sophie; Nagel, Eike; Greil, Gerald F
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This article is from Journal of Cardiovascular Magnetic Resonance , volume 16 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042229
PubMed Central
by Hartlage, Gregory; Hayek, Salim; Babaliaros, Vasilis; Keegan, Patricia; Thourani, Vinod; Lerakis, Stamatios
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This article is from Journal of Cardiovascular Magnetic Resonance , volume 16 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042286
PubMed Central
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This article is from Molecular Cytogenetics , volume 7 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042350
PubMed Central
by Feliciano, Helene; Stuber, Matthias; van Heeswijk, Ruud B
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This article is from Journal of Cardiovascular Magnetic Resonance , volume 16 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042471
PubMed Central
by Abbott, Jamie A.; Francklyn, Christopher S.; Robey-Bond, Susan M.
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This article is from Frontiers in Genetics , volume 5 . Abstract Pathological mutations in tRNA genes and tRNA processing enzymes are numerous and result in very complicated clinical phenotypes. Mitochondrial tRNA (mt-tRNA) genes are “hotspots” for pathological mutations and over 200 mt-tRNA mutations have been linked to various disease states. Often these mutations prevent tRNA aminoacylation. Disrupting this primary function affects protein synthesis and the expression, folding, and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042891
PubMed Central
by Kuhara, Shigehide; Nitta, Shuhei; Shiodera, Taichiro; Sakata, Yukinobu; Takeguchi, Tomoyuki; Yokoyama, Kenichi; Ishimura, Reiko; Kariyasu, Toshiya; Imai, Masamichi; Nitatori, Toshiaki; Albert, Timothy
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This article is from Journal of Cardiovascular Magnetic Resonance , volume 16 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043459
PubMed Central
by CHEN, YUEFU; LIU, YAJIE; LUO, CHENGHONG; LU, WEIHENG; SU, BINRU
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This article is from Experimental and Therapeutic Medicine , volume 7 . Abstract In order to identify the potential factors involved in the development of acute progressive cerebral infarction (PCI), the association between potential risk factors and extra- and intracranial arterial lesions was investigated. A total of 608 patients underwent cerebral angiography to analyze the morphological characteristics between the PCI and NPCI groups. In addition, data from numerous cases of extra- and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043577
PubMed Central
by Cheng, Tao; Wicks, Thomas
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This article is from PLoS ONE , volume 9 . Abstract Background: Every day, around 400 million tweets are sent worldwide, which has become a rich source for detecting, monitoring and analysing news stories and special (disaster) events. Existing research within this field follows key words attributed to an event, monitoring temporal changes in word usage. However, this method requires prior knowledge of the event in order to know which words to follow, and does not guarantee that the words...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043742
PubMed Central
by Ahlman, Mark A; Raman, Fabio S; Penzak, Scott R; Pang, Jianing; Li, Debiao; Bluemke, David
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This article is from Journal of Cardiovascular Magnetic Resonance , volume 16 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043685