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by Tantra, Martesa; Hammer, Christian; Kastner, Anne; Dahm, Liane; Begemann, Martin; Bodda, Chiranjeevi; Hammerschmidt, Kurt; Giegling, Ina; Stepniak, Beata; Castillo Venzor, Aracely; Konte, Bettina; Erbaba, Begun; Hartmann, Annette; Tarami, Asieh; Schulz-Schaeffer, Walter; Rujescu, Dan; Mannan, Ashraf U; Ehrenreich, Hannelore
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This article is from EMBO Molecular Medicine , volume 6 . Abstract The X-chromosomal MECP2/Mecp2 gene encodes methyl-CpG-binding protein 2, a transcriptional activator and repressor regulating many other genes. We discovered in male FVB/N mice that mild (∼50%) transgenic overexpression of Mecp2 enhances aggression. Surprisingly, when the same transgene was expressed in C57BL/6N mice, transgenics showed reduced aggression and social interaction. This suggests that Mecp2 modulates aggressive...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023888
PubMed Central
by Salles, Frederico F.; Gattolliat, Jean-Luc; Angeli, Kamila B.; De-Souza, Marcia R.; Goncalves, Ines C.; Nessimian, Jorge L.; Sartori, Michel
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This article is from ZooKeys . Abstract AbstractDespite its wide, almost worldwide distribution, the mayfly genus Cloeon Leach, 1815 (Ephemeroptera: Baetidae) is restricted in the Western hemisphere to North America, where a single species is reported. In the Neotropics, except for some species wrongly attributed to the genus in the past, there are no records of Cloeon. Recently, however, specimens of true Cloeon were collected along the coast of Espírito Santo, Southeastern Brazil. In order...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023231
PubMed Central
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This article is from ZooKeys . Abstract AbstractThe Taiwanese species of the genus Paridea Baly, 1886, are revised. Two new species, Paridea (Semacia) houjayisp. n. and P. (S.) kaoisp. n. are described. Both were confused previously with P. (S.) sexmaculata (Laboissière, 1930) and P. (S.) angulicollis (Motschulsky, 1854) respectively. Paridea (P.) sauteri (Chûjô, 1935) and P. (P.) taiwana (Chûjô, 1935) are removed from synonymy with P. (P.) sinensis Laboissière, 1930. The synonymy of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023269
PubMed Central
by Minervini, Andrea; Vittori, Gianni; Siena, Giampaolo; Carini, Marco
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This article is from Asian Journal of Andrology , volume 16 . Abstract Currently transrectal ultrasound-guided prostate biopsy (TRUS-Bx) is one of the most common urological procedures, with more than 1 million performed per year in Europe and the United States.1 Among patients undergoing TRUS-Bx, approximately one-third will receive a diagnosis of prostate cancer (PCa), while two-thirds receive a negative result on initial biopsy. Negative biopsy patients maintain an estimated risk of repeated...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023369
PubMed Central
by Wirawan, Adrianto; Harris, Robert S; Liu, Yongchao; Schmidt, Bertil; Schroder, Jan
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This article is from BMC Bioinformatics , volume 15 . Abstract Background: Current-generation sequencing technologies are able to produce low-cost, high-throughput reads. However, the produced reads are imperfect and may contain various sequencing errors. Although many error correction methods have been developed in recent years, none explicitly targets homopolymer-length errors in the 454 sequencing reads. Results: We present HECTOR, a parallel multistage homopolymer spectrum based error...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023493
This article is from BMC Medical Research Methodology , volume 14 . Abstract Background: The DerSimonian and Laird approach (DL) is widely used for random effects meta-analysis, but this often results in inappropriate type I error rates. The method described by Hartung, Knapp, Sidik and Jonkman (HKSJ) is known to perform better when trials of similar size are combined. However evidence in realistic situations, where one trial might be much larger than the other trials, is lacking. We aimed to...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015721
PubMed Central
by Delangue, Julie; Roca Sanchez, Yelin; Piorkowski, Geraldine; Bessaud, Mael; Baronti, Cecile; Thirion-Perrier, Laurence; Mafayle, Roxana Loayza; Ardaya, Cinthia Avila; Aguilera, Gabriela Anez; Guzman, Jimmy Revollo; Riera, Javier Lora; de Lamballerie, Xavier
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This article is from Virology Journal , volume 11 . Abstract Background: Acute respiratory infections represent a serious public health issue worldwide but virological aetiologies of Influenza Like Illnesses (ILIs) remain largely unknown in developing countries. This study represents the first attempt to characterise viral aetiologies of ILIs in Bolivia. Methods: It was performed in Santa Cruz city from January 2010 to September 2012, based on 564 naso-pharyngeal swabs collected in a National...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015617
PubMed Central
by Kearley, Karen; Selwood, Mary; Van den Bruel, Ann; Thompson, Matthew; Mant, David; Hobbs, FD Richard; Fitzmaurice, David; Heneghan, Carl
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This article is from BMJ Open , volume 4 . Abstract Objective: New electronic devices offer an opportunity within routine primary care settings for improving the detection of atrial fibrillation (AF), which is a common cardiac arrhythmia and a modifiable risk factor for stroke. We aimed to assess the performance of a modified blood pressure (BP) monitor and two single-lead ECG devices, as diagnostic triage tests for the detection of AF. Setting: 6 General Practices in the UK. Participants: 1000...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025411
PubMed Central
by Wang, Xiaolu; Gao, Haitao; Ren, Lixin; Gu, Junfei; Zhang, Yanping; Zhang, Yong
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This article is from BMC Cancer , volume 14 . Abstract Background: Androgen deprivation therapy is the primary strategy for the treatment of advanced prostate cancer; however, after an initial regression, most patients will inevitably develop a fatal androgen-independent tumor. Therefore, understanding the mechanisms of the transition to androgen independence prostate cancer is critical to identify new ways to treat older patients who are ineligible for conventional chemotherapy. Methods: The...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024097
PubMed Central
by Valiathan, Ranjini; Miguez, Maria J.; Patel, Bijal; Arheart, Kristopher L.; Asthana, Deshratn
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This article is from PLoS ONE , volume 9 . Abstract Background: The influence of tobacco smoking on the immune system of HIV infected individuals is largely unknown. We investigated the impact of tobacco smoking on immune activation, microbial translocation, immune exhaustion and T-cell function in HIV infected individuals. Method: HIV infected smokers and non-smokers (n = 25 each) with documented viral suppression on combination antiretroviral therapy and HIV uninfected smokers and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026405
PubMed Central
by Yasser, Mohd; Shaikh, Rubina; Chilakapati, Murali Krishna; Teni, Tanuja
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This article is from PLoS ONE , volume 9 . Abstract Radiotherapy is an important treatment modality for oral cancer. However, development of radioresistance is a major hurdle in the efficacy of radiotherapy in oral cancer patients. Identifying predictors of radioresistance is a challenging task and has met with little success. The aim of the present study was to explore the differential spectral profiles of the established radioresistant sublines and parental oral cancer cell lines by Raman...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026477
PubMed Central
by Abdalla, Hiba; Wilding, Craig S; Nardini, Luisa; Pignatelli, Patricia; Koekemoer, Lizette L; Ranson, Hilary; Coetzee, Maureen
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This article is from Parasites & Vectors , volume 7 . Abstract Background: Malaria vector control in Sudan relies mainly on indoor residual spraying (IRS) and the use of long lasting insecticide treated bed nets (LLINs). Monitoring insecticide resistance in the main Sudanese malaria vector, Anopheles arabiensis, is essential for planning and implementing an effective vector control program in this country. Methods: WHO susceptibility tests were used to monitor resistance to insecticides...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026821
PubMed Central
by Katz, Jeffrey N; Perez, Maria T; Niu, Nina N; Dong, Yan; Brownlee, Sarah A; Elman, Scott A; Stenquist, Derek S; Santiago, Adianez; Sanchez, Edward S; Collins, Jamie E
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This article is from BMC Musculoskeletal Disorders , volume 15 . Abstract Background: Valid measures of physical activity are critical research tools. The objective of this study was to develop a Spanish translation of the Yale Physical Activity Survey, and to provide preliminary evidence of its validity in a population of Dominican patients with lower extremity arthritis. Methods: A Dominican bilingual health care professional translated the Yale Physical Activity Survey (YPAS) from English to...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027998
PubMed Central
by Figley, Sarah A.; Liu, Yang; Karadimas, Spyridon K.; Satkunendrarajah, Kajana; Fettes, Peter; Spratt, S. Kaye; Lee, Gary; Ando, Dale; Surosky, Richard; Giedlin, Martin; Fehlings, Michael G.
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This article is from PLoS ONE , volume 9 . Abstract Following spinal cord injury (SCI) there are drastic changes that occur in the spinal microvasculature, including ischemia, hemorrhage, endothelial cell death and blood-spinal cord barrier disruption. Vascular endothelial growth factor-A (VEGF-A) is a pleiotropic factor recognized for its pro-angiogenic properties; however, VEGF has recently been shown to provide neuroprotection. We hypothesized that delivery of AdV-ZFP-VEGF – an...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028194
PubMed Central
by Wang, Huaquan; Tu, Meifeng; Fu, Rong; Wu, Yuhong; Liu, Hong; Xing, Limin; Shao, Zonghong
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This article is from PLoS ONE , volume 9 . Abstract Hepatitis-associated aplastic anemia (HAAA) is a variant of severe aplastic anemia (SAA) in which bone marrow failure follows an acute attack of hepatitis. Its pathogenesis is poorly understood. We investigated the prevalence of HAAA among cases of newly diagnosed SAA presenting to our hospital between January 1998 and February 2013, and analyzed the clinical and immune characteristics of HAAA and non-hepatitis-associated SAA (non-HASAA)...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028298
PubMed Central
by Elhassan, Nuha; Gebremeskel, Eyoab Iyasu; Elnour, Mohamed Ali; Isabirye, Dan; Okello, John; Hussien, Ayman; Kwiatksowski, Dominic; Hirbo, Jibril; Tishkoff, Sara; Ibrahim, Muntaser E.
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This article is from PLoS ONE , volume 9 . Abstract Human genetic variation particularly in Africa is still poorly understood. This is despite a consensus on the large African effective population size compared to populations from other continents. Based on sequencing of the mitochondrial Cytochrome C Oxidase subunit II (MT-CO2), and genome wide microsatellite data we observe evidence suggesting the effective size (Ne) of humans to be larger than the current estimates, with a foci of increased...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028218
PubMed Central
by Wei, Gao-Xia; Dong, Hao-Ming; Yang, Zhi; Luo, Jing; Zuo, Xi-Nian
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This article is from Frontiers in Aging Neuroscience , volume 6 . Abstract Whether Tai Chi Chuan (TCC) can influence the intrinsic functional architecture of the human brain remains unclear. To examine TCC-associated changes in functional connectomes, resting-state functional magnetic resonance images were acquired from 40 older individuals including 22 experienced TCC practitioners (experts) and 18 demographically matched TCC-naïve healthy controls, and their local functional homogeneities...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029006
PubMed Central
by Banos, Oresti; Galvez, Juan-Manuel; Damas, Miguel; Pomares, Hector; Rojas, Ignacio
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This article is from Sensors (Basel, Switzerland) , volume 14 . Abstract Signal segmentation is a crucial stage in the activity recognition process; however, this has been rarely and vaguely characterized so far. Windowing approaches are normally used for segmentation, but no clear consensus exists on which window size should be preferably employed. In fact, most designs normally rely on figures used in previous works, but with no strict studies that support them. Intuitively, decreasing the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029702
PubMed Central
by Zhang, Zheng; Ding, Liping; Jin, Zhitao; Gao, Guojie; Li, Huijun; Zhang, Lijuan; Zhang, Lina; Lu, Xin; Hu, Lihua; Lu, Bingwei; Yu, Xiongjun; Hu, Taohong
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This article is from PLoS ONE , volume 9 . Abstract Nebivolol, third-generation β-blocker, may activate β3-adrenergic receptor (AR), which has been emerged as a novel and potential therapeutic targets for cardiovascular diseases. However, it is not known whether nebivolol administration plays a cardioprotective effect against myocardial infarction (MI) injury. Therefore, the present study was designed to clarify the effects of nebivolol on MI injury and to elucidate the underlying mechanism....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029889
PubMed Central
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This article is from Healthcare Informatics Research , volume 20 . Abstract Objectives: The purpose of this study was to identify the effects of hospitals' innovativeness on outsourcing decision-making regarding four information system (IS) functions, namely, software programs, network maintenance, hardware systems, and PC/printer maintenance. Methods: Using the 2011 roster of the Korean Hospital Association, this study selected 311 general hospitals as a study population. After identifying the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030057
PubMed Central
by Maciejasz, Pawel; Eschweiler, Jorg; Gerlach-Hahn, Kurt; Jansen-Troy, Arne; Leonhardt, Steffen
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This article is from Journal of NeuroEngineering and Rehabilitation , volume 11 . Abstract The existing shortage of therapists and caregivers assisting physically disabled individuals at home is expected to increase and become serious problem in the near future. The patient population needing physical rehabilitation of the upper extremity is also constantly increasing. Robotic devices have the potential to address this problem as noted by the results of recent research studies. However, the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029785
PubMed Central
by Parkinson, Erika; Skipp, Paul; Aleksic, Maja; Garrow, Andrew; Dadd, Tony; Hughes, Michael; Clough, Geraldine; O?Connor, C. David
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This article is from PLoS ONE , volume 9 . Abstract Background: Skin has a variety of functions that are incompletely understood at the molecular level. As the most accessible tissue in the body it often reveals the first signs of inflammation or infection and also represents a potentially valuable source of biomarkers for several diseases. In this study we surveyed the skin proteome qualitatively using gel electrophoresis, liquid chromatography tandem mass spectrometry (GeLC-MS/MS) and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029809
PubMed Central
by Payne, Roxanne; Glenn, Lyn; Hoen, Helena; Richards, Beverley; Smith, John W; Lufkin, Robert; Crocenzi, Todd S; Urba, Walter J; Curti, Brendan D
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This article is from Journal for Immunotherapy of Cancer , volume 2 . Abstract Background: High-dose interleukin-2 (IL-2) has been FDA-approved for over 20 years, but it is offered only at a small number of centers with expertise in its administration. We analyzed the outcomes of patients receiving high-dose IL-2 in relation to the severity of toxicity to ascertain if response or survival were adversely affected. Methods: A retrospective analysis of the outcomes of 500 patients with metastatic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030280
PubMed Central
by Lakshmi, Sristi; Nath, Amiya Kumar; Udayashankar, Carounanidy
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This article is from Indian Dermatology Online Journal , volume 5 . Abstract Background:: Psoriasis patients are at increased risk of developing the metabolic syndrome (MS). Proinflammatory cytokines such as tumor necrosis factor-α, interleukin-6 that are increased in the psoriatic plaques are known to contribute to features of MS such as hypertension, dyslipidemia and insulin resistance. Aims:: (1) To establish the frequency of MS in patients with psoriasis. (2) To study the risk factors...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030337
PubMed Central
by Faulwetter, Sarah; Markantonatou, Vasiliki; Pavloudi, Christina; Papageorgiou, Nafsika; Keklikoglou, Kleoniki; Chatzinikolaou, Eva; Pafilis, Evangelos; Chatzigeorgiou, Georgios; Vasileiadou, Katerina; Dailianis, Thanos; Fanini, Lucia; Koulouri, Panayota; Arvanitidis, Christos
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This article is from Biodiversity Data Journal . Abstract AbstractThe study of ecosystem functioning – the role which organisms play in an ecosystem – is becoming increasingly important in marine ecological research. The functional structure of a community can be represented by a set of functional traits assigned to behavioural, reproductive and morphological characteristics. The collection of these traits from the literature is however a laborious and time-consuming process, and gaps of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030217
PubMed Central
by Guell, Oriol; Sagues, Francesc; Serrano, M. Angeles
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This article is from PLoS Computational Biology , volume 10 . Abstract We unravel how functional plasticity and redundancy are essential mechanisms underlying the ability to survive of metabolic networks. We perform an exhaustive computational screening of synthetic lethal reaction pairs in Escherichia coli in a minimal medium and we find that synthetic lethal pairs divide in two different groups depending on whether the synthetic lethal interaction works as a backup or as a parallel use...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031049
PubMed Central
by Teixeira, Frederico; Moutinho, Vitor; Akaishi, Eduardo; Mendes, Gabriella; Perina, Andre; Lima, Tiberio; Lallee, Margareth; Couto, Sergio; Utiyama, Edivaldo; Rasslan, Samir
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This article is from World Journal of Surgical Oncology , volume 12 . Abstract Popliteal lymph node dissection is performed when grossly metastatic nodal disease is encountered in the popliteal fossa or after microscopic metastasis is found in interval sentinel nodes during clinical staging of cutaneous malignant melanoma. Initially, an S-shaped incision is made to gain access to the popliteal fossa. A careful en bloc removal of fat tissue and lymph nodes is made to preserve and avoid the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031375
PubMed Central
by Canestrelli, Daniele; Bisconti, Roberta; Sacco, Florinda; Nascetti, Giuseppe
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This article is from Scientific Reports , volume 4 . Abstract Hotspots of genetic diversity are regions of utmost importance for species survival and conservation, and their intimate link with the geographic location of glacial refugia has been well established. Nonetheless, the microevolutionary processes underlying the generation of hotspots in such regions have only recently become a fervent field of research. We investigated the phylogeographic and population genetic structure of the agile...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031470
This article is from BMC Research Notes , volume 7 . Abstract Background: Viral hepatitis exists throughout the world and is a major global public health problem affecting millions of people. Hepatitis B (HBV) and hepatitis C (HCV) virus are the commonest causes of inflammation of the liver leading to chronic liver disease, cirrhosis, hepatocellular carcinoma and even fulminant hepatitis. The objective of this retrospective study was to determine the prevalence of infections with HBV and HCV...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032359
PubMed Central
by Saradalekshmi, Koramannil Radha; Neetha, Nanoth Vellichiramal; Sathyan, Sanish; Nair, Indu V.; Nair, Chandrasekharan M.; Banerjee, Moinak
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This article is from PLoS ONE , volume 9 . Abstract DNA methylation has been implicated in the etiopathology of various complex disorders. DNA methyltransferases are involved in maintaining and establishing new methylation patterns. The aim of the present study was to investigate the inherent genetic variations within DNA methyltransferase genes in predisposing to susceptibility to schizophrenia. We screened for polymorphisms in DNA methyltransferases, DNMT1, DNMT3A, DNMT3B and DNMT3L in 330...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032286
PubMed Central
by Zhao, Jing; Yao, Peijun; Chen, Zhi; Li, Meiyan; Shen, Yang; Miao, Huamao; Zhou, Xingtao
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This article is from BMC Ophthalmology , volume 14 . Abstract Background: The novel Femtosecond lenticule extraction (FLEx) procedure has been considered safe, predictable, and effective in treating myopia and myopic astigmatism, with few complications. However, an enhancement procedure after FLEx may be required in some cases, but has not been reported in detail. Case presentation: A 24-year-old woman who had undergone bilateral FLEx with the VisuMax femtosecond laser treatment for myopic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032486
PubMed Central
by Luke, Amy; Bovet, Pascal; Plange-Rhule, Jacob; Forrester, Terrence E; Lambert, Estelle V; Schoeller, Dale A; Dugas, Lara R; Durazo-Arvizu, Ramon A; Shoham, David A; Cao, Guichan; Brage, Soren; Ekelund, Ulf; Cooper, Richard S
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This article is from BMC Public Health , volume 14 . Abstract Background: Examination of patterns and intensity of physical activity (PA) across cultures where obesity prevalence varies widely provides insight into one aspect of the ongoing epidemiologic transition. The primary hypothesis being addressed is whether low levels of PA are associated with excess weight and adiposity. Methods: We recruited young adults from five countries (500 per country, 2500 total, ages 25–45 years), spanning...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031970
PubMed Central
by Rathi, Manish; Gundlapalli, Srikant; Ramachandran, Raja; Mohindra, Sandeep; Kaur, Harsimran; Kumar, Vivek; Kohli, Harbir Singh; Gupta, Krishan Lal; Sakhuja, Vinay
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This article is from BMC Infectious Diseases , volume 14 . Abstract Background: Renal transplant recipients are at high risk of developing multiple infections, often concomitantly because of their immunocompromised status. Post renal transplant infections are often elusive and require extensive evaluation for proper diagnosis and treatment. A high index of suspicion is required and an attempt should be made to confirm the microbiological diagnosis from each site involved to rule out multiple...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032160
PubMed Central
by Evans, Ruth EC; Morris, Melanie; Sekhon, Mandeep; Buszewicz, Marta; Walter, Fiona M; Waller, Jo; Simon, Alice E
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This article is from The British Journal of General Practice , volume 64 . Abstract Background: In the UK there has been an effort, through the National Awareness and Early Diagnosis Initiative (NAEDI), to increase early stage diagnoses and ultimately cancer survival. Encouraging early symptom presentation through awareness-raising activities in primary care is one method to achieve this goal. Understanding GPs’ views about this type of activity, however, is crucial prior to implementation....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032020
PubMed Central
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This article is from Frontiers in Neural Circuits , volume 8 . Abstract Central auditory neurons that localize sound in horizontal space have specialized intrinsic and synaptic cellular mechanisms to tightly control the threshold and timing for action potential generation. However, the critical interplay between intrinsic voltage-gated conductances and extrinsic synaptic conductances in determining neuronal output are not well understood. In chicken, neurons in the nucleus laminaris (NL) encode...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033047
PubMed Central
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This article is from Frontiers in Endocrinology , volume 5 . Abstract Cerebellum development is sensitive to thyroid hormone (TH) levels, as THs regulate neuronal migration, differentiation, and myelination. Most effects of THs are mediated by the thyroid hormone receptor (TR) isoforms TRβ1, TRβ2, and TRα1. Studies aimed at identifying TH target genes during cerebellum development have only achieved partial success, as some of these genes do not possess classical TH-responsive elements, and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033007
PubMed Central
by Lim, Jeremiah K. H.; Nguyen, Christine T. O.; He, Zheng; Vingrys, Algis J.; Bui, Bang V.
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This article is from PLoS ONE , volume 9 . Abstract Purpose: To investigate the effect of ageing on the recovery of ocular blood flow, intravitreal oxygen tension and retinal function during and after intraocular pressure (IOP) elevation. Methods: Long Evans rats (3- and 14-month-old) underwent acute stepwise IOP elevation from 10 to 120 mmHg (5 mmHg steps each 3 minutes). IOP was then returned to baseline and recovery was monitored for 2 hours. Photopic electroretinograms (ERG) were recorded...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035318
PubMed Central
by Ojha, Saroj Prasad; Sigdel, Suraj; Meyer-Thompson, Hans-Gunter; Oechsler, Harald; Verthein, Uwe
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This article is from Harm Reduction Journal , volume 11 . Abstract Background: Data of the Central Bureau of Statistic of Nepal from 2008 show a total of more than 46,000 illegal drug users, out of which 61% are injecting drug users (IDU). An injecting mix of medicines like opioids, benzodiazepines and antihistamines (the so-called South Asian cocktail) was prevalent. Furthermore, it is estimated that about 70,000 people are living with human immunodeficiency virus (HIV). The government of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035730
PubMed Central
by Yamada, Ryosuke; Yoshie, Toshihide; Wakai, Satoshi; Asai-Nakashima, Nanami; Okazaki, Fumiyoshi; Ogino, Chiaki; Hisada, Hiromoto; Tsutsumi, Hiroko; Hata, Yoji; Kondo, Akihiko
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This article is from Microbial Cell Factories , volume 13 . Abstract Background: Kojic acid (5-Hydroxy-2-(hydroxymethyl)-4-pyrone) is one of the major secondary metabolites in Aspergillus oryzae. It is widely used in food, pharmaceuticals, and cosmetics. The production cost, however, is too high for its use in many applications. Thus, an efficient and cost-effective kojic acid production process would be valuable. However, little is known about the complete set of genes for kojic acid...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035902
PubMed Central
by Harnof, Sagi; Zibly, Zion; Shay, Lilach; Dogadkin, Osnat; Hanannel, Arik; Inbar, Yael; Goor-Aryeh, Itay; Caspi, Israel
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This article is from Journal of Therapeutic Ultrasound , volume 2 . Abstract Study design: A phantom experiment, two thermocouple experiments, three in vivo pig experiments, and a simulated treatment on a healthy human volunteer were conducted to test the feasibility, safety, and efficacy of magnetic resonance-guided focused ultrasound (MRgFUS) for treating facet joint pain. Objective: The goal of the current study was to develop a novel method for accurate and safe noninvasive facet joint...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036610
PubMed Central
by Silva, Felipe C; Lisboa, Bianca CG; Figueiredo, Marcia CP; Torrezan, Giovana T; Santos, Erika MM; Krepischi, Ana C; Rossi, Benedito M; Achatz, Maria I; Carraro, Dirce M
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This article is from BMC Medical Genetics , volume 15 . Abstract Background: Germ line mutations in BRCA1 and BRCA2 (BRCA1/2) and other susceptibility genes have been identified as genetic causes of hereditary breast and ovarian cancer (HBOC). To identify the disease-causing mutations in a cohort of 120 Brazilian women fulfilling criteria for HBOC, we carried out a comprehensive screening of BRCA1/2, TP53 R337H, CHEK2 1100delC, followed by an analysis of copy number variations in 14 additional...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038072
PubMed Central
by Kazmierczak, Maciej; Szczepaniak, Andrzej; Czyz, Anna; Rupa-Matysek, Joanna; Komarnicki, Mieczyslaw
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This article is from Contemporary Oncology , volume 18 . Abstract Spontaneous remission (SR) of acute myeloid leukemia (AML) in adults is observed very rarely. To date, about 100 cases have been presented in the literature. To our best knowledge, we describe the first adult Polish patient suffering from acute myelomonocytic leukemia (48, XY, +13, +21/46, XY), in whom after supportive therapy, including non-irradiated, non-leukocyte depleted red cell transfusions and low-dose corticosteroid, we...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037986
PubMed Central
by Liang, Jun-Li; Ren, Xiao-Cang; Lin, Qiang
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This article is from OncoTargets and therapy , volume 7 . Abstract Icotinib hydrochloride is an orally administered small-molecule reversible tyrosine kinase inhibitor that has been independently researched and developed and has independent intellectual property rights in the People’s Republic of China. Clinical trials have demonstrated that the response to icotinib among advanced non-small-cell lung cancer (NSCLC) patients who received at least one platinum-based chemotherapy regimen was not...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037325
PubMed Central
by Hsin, Jing-Ping; Li, Wencheng; Hoque, Mainul; Tian, Bin; Manley, James L
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This article is from eLife , volume 3 . Abstract The RNA polymerase II largest subunit (Rpb1) contains a unique C-terminal domain (CTD) that plays multiple roles during transcription. The CTD is composed of consensus Y1S2P3T4S5P6S7 repeats, in which Ser, Thr and Tyr residues can all be phosphorylated. Here we report analysis of CTD Tyr1 using genetically tractable chicken DT40 cells. Cells expressing an Rpb1 derivative with all Tyr residues mutated to Phe (Rpb1-Y1F) were inviable. Remarkably,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042873
PubMed Central
by Gottlieb, Ilan; Camargo, Gabriel; Derenne, Maria Eduarda; Sabioni, Leticia R; Naue, Vania M; Rothstein, Tamara; Strecker, Ralph; Greiser, Andreas; Lima, Ronaldo S
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This article is from Journal of Cardiovascular Magnetic Resonance , volume 16 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4044223
PubMed Central
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This article is from Retrovirology , volume 11 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4044639
PubMed Central
by Twigger, Katie; Rowan, Aileen; Seich al Basatena, Nafisa-Katrin; MacNamara, Aidan; Retiere, Christelle; Gould, Keith; Taylor, Graham P; Asquith, Becca; Bangham, Charles RM
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This article is from Retrovirology , volume 11 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4044156
PubMed Central
by Khan, Sarah N; Moghaddam, Abbas N; Kaveh, Razieh; Plotnik, Adam; Lehrman, Evan; Nsair, Ali; Paul Finn, J
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This article is from Journal of Cardiovascular Magnetic Resonance , volume 16 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045827
PubMed Central
by Baksi, Arun J; Roberts, Angharad M; Ware, James S; Gulati, Ankur; Buchan, Rachel J; Walsh, Roddy; John, Shibu; Wilkinson, Samuel; Ali, Aamir; Assomull, Ravi G; Barton, Paul J; Prasad, Sanjay K; Pennell, Dudley J; Cook, Stuart A
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This article is from Journal of Cardiovascular Magnetic Resonance , volume 16 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045251
PubMed Central
by Xiang, Yue; Liu, Wei; Chen, Yue; Zhang, Chuntao; Su, Weiheng; Zhang, Yan; Sun, Jiaxi; Gao, Feng; Jiang, Chunlai
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This article is from PLoS ONE , volume 9 . Abstract The majority of HIV-1 strains enter CD4+ T cells using the CCR5 and/or CXCR4 co-receptor. However, we recently identified a transmitted/founder (T/F) virus (ZP6248) that efficiently used an alternative coreceptor GPR15, rather than commonly used CXCR4 and CCR5, to establish clinical infection. To understand which regions in the env gene were critical for the atypical coreceptor usage, we generated a set of V3 mutants and determined their...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045670
PubMed Central
by Yamagishi, Tomoko; Ochi, Nobuaki; Yamane, Hiromichi; Hasebe, Satoshi; Takigawa, Nagio
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This article is from BMC Research Notes , volume 7 . Abstract Background: Docetaxel is a key antineoplastic drug for treatment of non-small cell lung cancer. Ocular adverse events of docetaxel include epiphora (excess tearing) and conjunctivitis. Epiphora has been reported to be associated with canalicular and nasolacrimal duct stenosis, but it is not necessarily caused by lacrimal duct obstruction. Case presentation: We encountered three Japanese non-small cell lung cancer patients who...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046091
PubMed Central
by Zhang, Hao; Gao, Jiyue; Zhao, Zuowei; Li, Man; Liu, Caigang
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This article is from BMC Cancer , volume 14 . Abstract Background: Certain markers have been identified over the last 10 years that facilitate the prediction of a patient’s prognosis; these markers have been proposed to be useful for risk stratification of lymphoma patients and for the development of specific therapeutic strategies. In the present study, we assessed the potential prognostic value of SPRR1A expression in 967 patients with diffuse large B-cell lymphomas. Methods: All patients...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046026
PubMed Central
by Vercruysse, Maarten; Kohrer, Caroline; Davies, Bryan W.; Arnold, Markus F. F.; Mekalanos, John J.; RajBhandary, Uttam L.; Walker, Graham C.
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This article is from PLoS Pathogens , volume 10 . Abstract YbeY, a highly conserved protein, is an RNase in E. coli and plays key roles in both processing of the critical 3′ end of 16 S rRNA and in 70 S ribosome quality control under stress. These central roles account for YbeY's inclusion in the postulated minimal bacterial genome. However, YbeY is not essential in E. coli although loss of ybeY severely sensitizes it to multiple physiological stresses. Here, we show that YbeY is an essential...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047096
PubMed Central
by Raz, Oshrat; Lev, Dorit L.; Battler, Alexander; Lev, Eli I.
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This article is from PLoS ONE , volume 9 . Abstract Introduction: Endothelial progenitor cells (EPCs) have an important role in the process of vascular injury repair. Platelets have been shown to mediate EPC recruitment, maturation and differentiation. Yet, the mechanism underlying this interaction is unclear. We, therefore, aimed to examine whether direct contact between platelets and EPCs is essential for the positive platelets-EPC effect, and to investigate the main mediators responsible for...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046960
PubMed Central
by Barbieri, Chiara; Vicente, Mario; Oliveira, Sandra; Bostoen, Koen; Rocha, Jorge; Stoneking, Mark; Pakendorf, Brigitte
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This article is from PLoS ONE , volume 9 . Abstract Bantu speech communities expanded over large parts of sub-Saharan Africa within the last 4000–5000 years, reaching different parts of southern Africa 1200–2000 years ago. The Bantu languages subdivide in several major branches, with languages belonging to the Eastern and Western Bantu branches spreading over large parts of Central, Eastern, and Southern Africa. There is still debate whether this linguistic divide is correlated with a...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047067
This article is from Journal of Physical Therapy Science , volume 26 . Abstract [Purpose] Many patients receive intermittent cervical traction in a daily treatment setting. However, unified settings for traction force, duration, and direction have yet to be determined. Therefore, an objective index is required to determine changes in traction conditions or to indicate its effectiveness. [Subjects] Fifteen healthy males volunteers participated in this study. [Methods] The thickness of the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047253
PubMed Central
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This article is from Cell Death & Disease , volume 5 . Abstract The disruption of DNA replication in cells triggers checkpoint responses that slow-down S-phase progression and protect replication fork integrity. These checkpoints are also determinants of cell fate and can help maintain cell viability or trigger cell death pathways. CHK1 has a pivotal role in such S-phase responses. It helps maintain fork integrity during replication stress and protects cells from several catastrophic fates...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047883
PubMed Central
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This article is from Frontiers in Computational Neuroscience , volume 8 . Abstract Cortical neurons receive barrages of excitatory and inhibitory inputs which are not independent, as network structure and synaptic kinetics impose statistical correlations. Experiments in vitro and in vivo have demonstrated correlations between inhibitory and excitatory synaptic inputs in which inhibition lags behind excitation in cortical neurons. This delay arises in feed-forward inhibition (FFI) circuits and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047963
PubMed Central
by Wang, Haiji; Xu, Chunyuan; Kong, Xiaoli; Li, Xiaoyan; Kong, Xiangnan; Wang, Yu; Ding, Xia; Yang, Qifeng
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This article is from PLoS ONE , volume 9 . Abstract Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can selectively induce apoptosis of cancer cells and is verified effective to various cancers. However, a variety of breast cancer cell lines are resistant to TRAIL and the mechanisms of resistance are largely unknown. In our present experiment, we successfully utilized breast cancer cell line MDA-MB-231 to establish TRAIL-resistant cell line. We found resistance to TRAIL could...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048247
PubMed Central
by Silfeler, Dilek Benk; Kurt, Raziye Keskin; Yengil, Erhan; Un, Burak; Arica, Secil; Baloglu, Ali
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This article is from Pakistan Journal of Medical Sciences , volume 30 . Abstract Objective: Mean Platelet Volume (MPV) is an important indicator of platelet activation. It is known that MPV increases in patients with coronory artery disease, diabetes mellitus, atherosclerosis and Polycystic ovary syndrome (PCOS). Our aim was to measure the MPV in lean patients with polycystic ovary syndrome.Methods: The present study was designed to examine the platelet function by measuring MPV in non-obese...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048512
PubMed Central
by Lai, Yongqing; Yu, Zuhu; Shi, Bentao; Ni, Liangchao; Liu, Yunchu; Yang, Shangqi
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This article is from Pakistan Journal of Medical Sciences , volume 30 . Abstract Objectives: Patients with idiopathic chronic scrotal pain are challenging to both the general practioner and urologist. In this study, we tried to recognize mild epididymitis as an underrecogniczed cause of idiopathic chronic scrotal pain.Methods: We described a consecutive series of 44 patients with idiopathic chronic scrotal pain characterized by mild scrotal pain, mild to moderate tenderness of epididymis...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048522
PubMed Central
by Chaudhari, Nitin Kaduba; Song, Min Young; Yu, Jong-Sung
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This article is from Scientific Reports , volume 4 . Abstract Human urine, otherwise potentially polluting waste, is an universal unused resource in organic form disposed by the human body. We present for the first time “proof of concept” of a convenient, perhaps economically beneficial, and innovative template-free route to synthesize highly porous carbon containing heteroatoms such as N, S, Si, and P from human urine waste as a single precursor for carbon and multiple heteroatoms. High...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049026
PubMed Central
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This article is from Malaria Journal , volume 13 . Abstract Background: Plasmodium ovale is relatively unfamiliar to Chinese staff engaged in malaria diagnosis. In 2013, dried blood spots of four unidentified but suspected ovale malaria samples were sent to the National Malaria Reference Laboratory (NMRL) for reconfirmation. Methods: Partial and complete, small, subunit ribosomal DNA (SSU rDNA) sequences of four samples were obtained with PCR-cloning-sequencing method. Obtained sequences were...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049480
PubMed Central
by Caljouw, Monique AA; Cools, Herman JM; Gussekloo, Jacobijn
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This article is from BMC Geriatrics , volume 14 . Abstract Background: Insight in the natural course of care dependency of vulnerable older persons in long-term care facilities (LTCF) is essential to organize and optimize individual tailored care. We examined changes in care dependency in LTCF residents over two 6-month periods, explored the possible predictive factors of change and the effect of care dependency on mortality. Methods: A prospective follow-up study in 21 Dutch long-term care...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049399
PubMed Central
by Lee, Bonggi; Qiao, Liping; Kinney, Brice; Feng, Gen-Sheng; Shao, Jianhua
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This article is from PLoS ONE , volume 9 . Abstract Increased macrophage infiltration in tissues including white adipose tissue and skeletal muscle has been recognized as a pro-inflammatory factor that impairs insulin sensitivity in obesity. However, the relationship between tissue macrophages and energy metabolism under non-obese physiological conditions is not clear. To study a homeostatic role of macrophages in energy homeostasis, we depleted tissue macrophages in adult mice through...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049836
PubMed Central
by Park, Myoung-Rin; Park, Yeon-Hee; Choi, Jae-Woo; Park, Dong-Il; Chung, Chae-Uk; Moon, Jae-Young; Park, Hee-Sun; Jung, Sung-Soo; Kim, Ju-Ock; Kim, Sun-Young; Lee, Jeong-Eun
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This article is from Tuberculosis and Respiratory Diseases , volume 76 . Abstract Background: Small cell lung cancer (SCLC) is an extremely aggressive tumor with a poor clinical course. Although many efforts have been made to improve patients' survival rates, patients who survive longer than 2 years after chemotherapy are still very rare. We examined the baseline characteristics of patients with long-term survival rates in order to identify the prognostic factors for overall survivals. Methods:...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050069
PubMed Central
by Liu, Ningning; Liu, Chunjiao; Li, Xiaofen; Liao, Siyan; Song, Wenbin; Yang, Changshan; Zhao, Chong; Huang, Hongbiao; Guan, Lixia; Zhang, Peiquan; Liu, Shouting; Hua, Xianliang; Chen, Xin; Zhou, Ping; Lan, Xiaoying; Yi, Songgang; Wang, Shunqing; Wang, Xuejun; Dou, Q. Ping; Liu, Jinbao
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This article is from Scientific Reports , volume 4 . Abstract The successful development of bortezomib-based therapy for treatment of multiple myeloma has established proteasome inhibition as an effective therapeutic strategy, and both 20S proteasome peptidases and 19S deubiquitinases (DUBs) are becoming attractive targets of cancer therapy. It has been reported that metal complexes, such as copper complexes, inhibit tumor proteasome. However, the involved mechanism of action has not been fully...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050382
PubMed Central
by Lehmkuhler, Felix; Gutt, Christian; Fischer, Birgit; Schroer, Martin A.; Sikorski, Marcin; Song, Sanghoon; Roseker, Wojciech; Glownia, James; Chollet, Mathieu; Nelson, Silke; Tono, Kensuke; Katayama, Tetsuo; Yabashi, Makina; Ishikawa, Tetsuya; Robert, Aymeric; Grubel, Gerhard
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This article is from Scientific Reports , volume 4 . Abstract We measured the coherence properties of the free-electron laser SACLA on a single shot basis at an X-ray energy of 8 keV. By analysing small-angle X-ray scattering speckle patterns from colloidal dispersions we found a degree of transverse coherence of βt = 0.79 ± 0.09. Taking detector properties into account, we developed a simulation model in oder to determine the degree of coherence from intensity histograms. Finally we...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050387
PubMed Central
by Wanjare, Maureen; Kusuma, Sravanti; Gerecht, Sharon
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This article is from Stem Cell Reports , volume 2 . Abstract Distinguishing between perivascular cell types remains a hurdle in vascular biology due to overlapping marker expressions and similar functionalities. Clarifying and defining heterogeneities in vitro among perivascular cells could lead to improved cell-based tissue regeneration strategies and a better understanding of human developmental processes. We studied contractile vascular smooth muscle cells (vSMCs), synthetic vSMCs, and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050491
PubMed Central
by Akarolo-Anthony, Sally N; Adebamowo, Clement A
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This article is from BMC Public Health , volume 14 . Abstract Background: Physical inactivity levels are rising in many countries with major implications for the prevalence of non-communicable diseases and the general health of the population worldwide. We conducted this study to examine leisure-time physical activity levels among African adults in an urban setting. Methods: We conducted a cross-sectional study among a random sample of 1,058 adults at a government worksite, in Abuja, an urban...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050994
This article is from Nanoscale Research Letters , volume 9 . Abstract The simple self-aligned photolithography technique and laser interference photolithography technique were proposed and utilized to fabricate multiple-gate ZnO metal-oxide-semiconductor field-effect transistors (MOSFETs). Since the multiple-gate structure could improve the electrical field distribution along the ZnO channel, the performance of the ZnO MOSFETs could be enhanced. The performance of the multiple-gate ZnO MOSFETs...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051410
PubMed Central
by Windhager, Sonja; Schaschl, Helmut; Schaefer, Katrin; Mitteroecker, Philipp; Huber, Susanne; Wallner, Bernard; Fieder, Martin
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This article is from PLoS ONE , volume 9 . Abstract Facial asymmetries are commonly used as a proxy for human developmental imprecision resulting from inbreeding, and thus reduced genetic heterozygosity. Several environmental factors influence human facial asymmetry (e.g., health care, parasites), but the generalizability of findings on genetic stressors has been limited in humans by sample characteristics (island populations, endogamy) and indirect genetic assessment (inference from...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051657
PubMed Central
by Ojovan, Silviya M.; McDonald, Mathew; Rabieh, Noha; Shmuel, Nava; Erez, Hadas; Nesladek, Milos; Spira, Micha E.
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This article is from Frontiers in Neuroengineering , volume 7 . Abstract Using a variety of proliferating cell types, it was shown that the surface of nanocrystalline diamond (NCD) provides a permissive substrate for cell adhesion and development without the need of complex chemical functionalization prior to cell seeding. In an extensive series of experiments we found that, unlike proliferating cells, post-mitotic primary neurons do not adhere to bare NCD surfaces when cultured in defined...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052739
PubMed Central
by McMullin, Ryan P; Wittner, Ben S; Yang, Chuanwei; Denton-Schneider, Benjamin R; Hicks, Daniel; Singavarapu, Raj; Moulis, Sharon; Lee, Jeongeun; Akbari, Mohammad R; Narod, Steven A; Aldape, Kenneth D; Steeg, Patricia S; Ramaswamy, Sridhar; Sgroi, Dennis C
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This article is from Breast Cancer Research : BCR , volume 16 . Abstract Introduction: There is an unmet clinical need for biomarkers to identify breast cancer patients at an increased risk of developing brain metastases. The objective is to identify gene signatures and biological pathways associated with human epidermal growth factor receptor 2-positive (HER2+) brain metastasis. Methods: We combined laser capture microdissection and gene expression microarrays to analyze malignant epithelium...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053087
PubMed Central
by Zhou, Xinghu; Bi, Bo; Zheng, Liqiang; Li, Zhao; Yang, Hongmei; Song, Hongjie; Sun, Yingxian
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This article is from PLoS ONE , volume 9 . Abstract Background: It is essential to understand how we can prevent and treat the epidemic of depression. Several studies have reported the prevalence of depressive symptoms in the urban population in China, but there is a lack of information regarding the prevalence of depression in rural populations. Objective: To understand the prevalence of depression in a rural Chinese population and to analyze the risk factors for depression. Methods: This...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053343
This article is from PLoS ONE , volume 9 . Abstract Insulin-like growth factor 1 (IGF-1) and hepatocyte growth factor (HGF) are two potent cell survival and regenerative factors in response to myocardial injury (MI). We hypothesized that simultaneous delivery of IGF+HGF combined with Sca-1+/CD31− cells would improve the outcome of transplantation therapy in response to the altered hostile microenvironment post MI. One million adenovirus nuclear LacZ-labeled Sca-1+/CD31− cells were injected...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053321
PubMed Central
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This article is from Genome Biology , volume 15 . Abstract Background: Epigenome-wide association studies of human disease and other quantitative traits are becoming increasingly common. A series of papers reporting age-related changes in DNA methylation profiles in peripheral blood have already been published. However, blood is a heterogeneous collection of different cell types, each with a very different DNA methylation profile. Results: Using a statistical method that permits estimating the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053810
PubMed Central
by Zhao, Shanshan; Chlebowski, Rowan T; Anderson, Garnet L; Kuller, Lewis H; Manson, JoAnn E; Gass, Margery; Patterson, Ruth; Rohan, Thomas E; Lane, Dorothy S; Beresford, Shirley AA; Lavasani, Sayeh; Rossouw, Jacques E; Prentice, Ross L
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This article is from Breast Cancer Research : BCR , volume 16 . Abstract Introduction: Paradoxically, a breast cancer risk reduction with conjugated equine estrogens (CEE) and a risk elevation with CEE plus medroxyprogesterone acetate (CEE + MPA) were observed in the Women’s Health Initiative (WHI) randomized controlled trials. The effects of hormone therapy on serum sex hormone levels, and on the association between baseline sex hormones and disease risk, may help explain these divergent...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053241
This article is from International Journal of Environmental Research and Public Health , volume 11 . Abstract Indoor air pollution caused by the indoor burning of solid biomass fuels has been associated with Acute Respiratory Infections such as pneumonia amongst children of less than five years of age. Behavioural change interventions have been identified as a potential strategy to reduce child indoor air pollution exposure, yet very little is known about the impact of behavioural change...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053881
PubMed Central
by Krisko, Anita; Copic, Tea; Gabaldon, Toni; Lehner, Ben; Supek, Fran
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This article is from Genome Biology , volume 15 . Abstract Background: The genetic code is redundant, meaning that most amino acids can be encoded by more than one codon. Highly expressed genes tend to use optimal codons to increase the accuracy and speed of translation. Thus, codon usage biases provide a signature of the relative expression levels of genes, which can, uniquely, be quantified across the domains of life. Results: Here we describe a general statistical framework to exploit this...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054840
PubMed Central
by Traeger, Adrian C; Moseley, G Lorimer; Hubscher, Markus; Lee, Hopin; Skinner, Ian W; Nicholas, Michael K; Henschke, Nicholas; Refshauge, Kathryn M; Blyth, Fiona M; Main, Chris J; Hush, Julia M; Pearce, Garry; McAuley, James H
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This article is from BMJ Open , volume 4 . Abstract Introduction: Low back pain (LBP) is the leading cause of disability worldwide. Of those patients who present to primary care with acute LBP, 40% continue to report symptoms 3 months later and develop chronic LBP. Although it is possible to identify these patients early, effective interventions to improve their outcomes are not available. This double-blind (participant/outcome assessor) randomised controlled trial will investigate the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054624
PubMed Central
by Navarro, Amparo; Marin, Severiano; Riol, Nicasia; Carbonell-Uberos, Francisco; Minana, Maria Dolores
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This article is from Stem Cell Research & Therapy , volume 5 . Abstract Introduction: Adipose tissue has the unique property of expanding throughout adult life, and angiogenesis is required for its growth. However, endothelial progenitor cells contribute minimally to neovascularization. Because myeloid cells have proven to be angiogenic, and monocytes accumulate in expanding adipose tissue, they might contribute to vascularization. Methods: The stromal vascular fraction (SVF) cells from...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055093
PubMed Central
by Fattah, Farjana J.; Hara, Kodai; Fattah, Kazi R.; Yang, Chenyi; Wu, Nan; Warrington, Ross; Chen, David J.; Zhou, Pengbo; Boothman, David A.; Yu, Hongtao
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This article is from PLoS Genetics , volume 10 . Abstract Translesion synthesis (TLS) enables DNA replication through damaged bases, increases cellular DNA damage tolerance, and maintains genomic stability. The sliding clamp PCNA and the adaptor polymerase Rev1 coordinate polymerase switching during TLS. The polymerases Pol η, ι, and κ insert nucleotides opposite damaged bases. Pol ζ, consisting of the catalytic subunit Rev3 and the regulatory subunit Rev7, then extends DNA synthesis past...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055408
PubMed Central
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This article is from Frontiers in Plant Science , volume 5 . Abstract We studied the photosynthetic activity of Scots pine (Pinus sylvestris L.) and Norway spruce (Picea abies [L.] Karst) in relation to air temperature changes from March 2013 to February 2014. We measured the chlorophyll fluorescence of approximately 50 trees of each species growing in southern Finland. Fluorescence was measured 1–3 times per week. We began by measuring shoots present in late winter (i.e., March 2013) before...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055857
PubMed Central
by Kaplan, Ryan A.; Enticott, Peter G.; Hohwy, Jakob; Castle, David J.; Rossell, Susan L.
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This article is from PLoS ONE , volume 9 . Abstract Evidence from past research suggests that behaviours and characteristics related to body dissatisfaction may be associated with greater instability of perceptual body image, possibly due to problems in the integration of body-related multisensory information. We investigated whether people with body dysmorphic disorder (BDD), a condition characterised by body image disturbances, demonstrated enhanced susceptibility to the rubber hand illusion...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055788
PubMed Central
by Drusco, Alessandra; Nuovo, Gerard J.; Zanesi, Nicola; Di Leva, Gianpiero; Pichiorri, Flavia; Volinia, Stefano; Fernandez, Cecilia; Antenucci, Anna; Costinean, Stefan; Bottoni, Arianna; Rosito, Immacolata A.; Liu, Chang-Gong; Burch, Aaron; Acunzo, Mario; Pekarsky, Yuri; Alder, Hansjuerg; Ciardi, Antonio; Croce, Carlo M.
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This article is from PLoS ONE , volume 9 . Abstract MicroRNAs are being exploited for diagnosis, prognosis and monitoring of cancer and other diseases. Their high tissue specificity and critical role in oncogenesis provide new biomarkers for the diagnosis and classification of cancer as well as predicting patients' outcomes. MicroRNAs signatures have been identified for many human tumors, including colorectal cancer (CRC). In most cases, metastatic disease is difficult to predict and to prevent...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055753
PubMed Central
by Wang, Weijia; Zhang, Xiuming; Ge, Na; Liu, Jing; Yuan, Huimin; Zhang, Peng; Liu, Wei; Wen, Dongmei
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This article is from Critical Care , volume 18 . Abstract Introduction: Procalcitonin (PCT) is a biomarker for the clinical diagnosis of bacterial infection that is more specific and earlier than fever, changes in white blood cell count, and blood cultures. Congestive heart failure is an important cause of endotoxin resorption from the intestine, which significantly increases PCT expression in noninfected patients with heart failure. The diagnostic performance and cut-off value of PCT in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056105
PubMed Central
by Yam, Hokchai; Abdul Rahim, Ainihayati; Mohamad, Suriani; Mahadi, Nor Muhammad; Abdul Manaf, Uyub; Shu-Chien, Alexander Chong; Najimudin, Nazalan
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This article is from PLoS ONE , volume 9 . Abstract Burkholderia pseudomallei is an opportunistic pathogen and the causative agent of melioidosis. It is able to adapt to harsh environments and can live intracellularly in its infected hosts. In this study, identification of transcriptional factors that associate with the β′ subunit (RpoC) of RNA polymerase was performed. The N-terminal region of this subunit is known to trigger promoter melting when associated with a sigma factor. A pull-down...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057154
PubMed Central
by Gu, Yanli; Shen, Xinghui; Zhou, Dongjie; Wang, Zhendong; Zhang, Na; Shan, Zhiyan; Jin, Lianhong; Lei, Lei
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This article is from PLoS ONE , volume 9 . Abstract Real-time reverse transcription quantitative polymerase chain reaction (qPCR) has become the most frequently used system for studies of gene expression. Manystudies have provided reliable evidence that the transcription levels of reference genes are not constant at different developmental stages and in different experimental conditions. However, suitable reference genes which are stably expressed in polyploid preimplantation embryos of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057156
This article is from BMC Research Notes , volume 7 . Abstract Background: Enormous volumes of short read data from next-generation sequencing (NGS) technologies have posed new challenges to the area of genomic sequence comparison. The multiple sequence alignment approach is hardly applicable to NGS data due to the challenging problem of short read assembly. Thus alignment-free methods are needed for the comparison of NGS samples of short reads. Results: Recently several k-mer based distance...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057587
PubMed Central
by Panneerselvam, Suresh; Choi, Sangdun
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This article is from International Journal of Molecular Sciences , volume 15 . Abstract Nanotechnology has arisen as a key player in the field of nanomedicine. Although the use of engineered nanoparticles is rapidly increasing, safety assessment is also important for the beneficial use of new nanomaterials. Considering that the experimental assessment of new nanomaterials is costly and laborious, in silico approaches hold promise. Several major challenges in nanotechnology indicate a need for...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057665
PubMed Central
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This article is from International Journal of Molecular Sciences , volume 15 . Abstract A variety of studies have suggested that the 4b/a polymorphism in the endothelial nitric oxide synthase (eNOS) was associated with coronary artery disease (CAD) risk. However, the data remain conflicting. The aim of the present meta-analysis was to estimate the overall association between risk of CAD and eNOS 4b/a polymorphism. Case-control, cohort or cross-sectional studies evaluating the association...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057714
PubMed Central
by Hill, James M.; Clement, Christian; Pogue, Aileen I.; Bhattacharjee, Surjyadipta; Zhao, Yuhai; Lukiw, Walter J.
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This article is from Frontiers in Aging Neuroscience , volume 6 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058571
PubMed Central
by Ren, Yahao; Ichinose, Takamichi; He, Miao; Song, Yuan; Yoshida, Yasuhiro; Yoshida, Seiichi; Nishikawa, Masataka; Takano, Hirohisa; Sun, Guifan; Shibamoto, Takayuki
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This article is from Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology , volume 10 . Abstract Background: A previous study has shown that the aggravation of Asian sand dust (ASD) on ovalbumin (OVA)-induced lung eosinphilia was more severe in lipopolysaccharide (LPS)-rich ASD than in SiO2-rich ASD. Therefore, the effects of different LPS contamination levels in ASD on the aggravation of OVA-induced lung eosinophilia were...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058696
PubMed Central
by Salonen, Anne H; Castren, Sari; Alho, Hannu; Lahti, Tuuli
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This article is from BMC Public Health , volume 14 . Abstract Background: Problem gambling not only impacts those directly involved, but also the concerned significant others (CSOs) of problem gamblers. The aims of this study were to investigate the proportion of male and female CSOs at the population level; to investigate who the CSOs were concerned about; and to investigate sociodemographic factors, gender differences, gambling behaviour, and health and well-being among CSOs and non-CSOs....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058717
PubMed Central
by Gong, Jingjing; Munoz, Amanda R.; Chan, Daniel; Ghosh, Rita; Kumar, Addanki P.
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This article is from Oncotarget , volume 5 . Abstract The dismal 5-year survival (
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058024
PubMed Central
by Aspesi, Anna; Pavesi, Elisa; Robotti, Elisa; Crescitelli, Rossella; Boria, Ilenia; Avondo, Federica; Moniz, Helene; Da Costa, Lydie; Mohandas, Narla; Roncaglia, Paola; Ramenghi, Ugo; Ronchi, Antonella; Gustincich, Stefano; Merlin, Simone; Marengo, Emilio; Ellis, Steven R.; Follenzi, Antonia; Santoro, Claudio; Dianzani, Irma
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This article is from Gene , volume 545 . Abstract Defects in genes encoding ribosomal proteins cause Diamond Blackfan Anemia (DBA), a red cell aplasia often associated with physical abnormalities. Other bone marrow failure syndromes have been attributed to defects in ribosomal components but the link between erythropoiesis and the ribosome remains to be fully defined. Several lines of evidence suggest that defects in ribosome synthesis lead to “ribosomal stress” with p53 activation and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058751
PubMed Central
by Shen, Huibin; Duhrkop, Kai; Bocker, Sebastian; Rousu, Juho
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This article is from Bioinformatics , volume 30 . Abstract Motivation: Metabolite identification from tandem mass spectrometric data is a key task in metabolomics. Various computational methods have been proposed for the identification of metabolites from tandem mass spectra. Fragmentation tree methods explore the space of possible ways in which the metabolite can fragment, and base the metabolite identification on scoring of these fragmentation trees. Machine learning methods have been used to...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058957
PubMed Central
by Jaramillo-Gonzalez, Luis Eduardo; Sanchez-Pedraza, Ricardo; Herazo, Maria Isabel
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This article is from BMC Psychiatry , volume 14 . Abstract Background: The rehospitalization of patients with mental disorders is common, with rehospitalization rates of up to 80% observed in these patients. This phenomenon negatively impacts families, patients, and the health care system. Several factors have been associated with an increased likelihood of rehospitalization. This study was aimed at determining the frequency and the factors associated with rehospitalization in a psychiatric...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059735
PubMed Central
by Chen, Tao; Koga, Kohei; Descalzi, Giannina; Qiu, Shuang; Wang, Jian; Zhang, Le-Shi; Zhang, Zhi-Jian; He, Xiao-Bin; Qin, Xin; Xu, Fu-Qiang; Hu, Ji; Wei, Feng; Huganir, Richard L; Li, Yun-Qing; Zhuo, Min
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This article is from Molecular Pain , volume 10 . Abstract Long-term potentiation (LTP) is the key cellular mechanism for physiological learning and pathological chronic pain. In the anterior cingulate cortex (ACC), postsynaptic recruitment or modification of AMPA receptor (AMPAR) GluA1 contribute to the expression of LTP. Here we report that pyramidal cells in the deep layers of the ACC send direct descending projecting terminals to the dorsal horn of the spinal cord (lamina I-III). After...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060852