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Klimik Dergisi (Klimik Journal)

Klimik Journal is the scientific, open-access and official publication of the Turkish Society of Clinical Microbiology and Infectious Diseases and is published four times per year, in March, June, September, and December.

Klimik Journal aims to publish high-quality basic and applied research articles on diagnosis, treatment, and prevention in infectious diseases, clinical microbiology, virology, parasitology, immunology, and epidemiology. In addition, reviews, editorial opinions, letters to the e...


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Objective : Mycoplasma hominis and Ureaplasma urealyticum are opportunistic pathogens which can frequently be isolated from genitourinary tracts in humans. The aim of this study was to evaluate the presence, epidemiologic features and antibiotic susceptibility of M. hominis and U. urealyticum agents in urine specimens which were sent from various clinics of Uludağ University, Hospital of Health Application and Research Center for diagnosis of genitourinary system infection. Methods : Urinary...
Topics: drug resistance, Mycoplasma hominis, Ureaplasma urealyticum
Klimik Dergisi (Klimik Journal)
by Zehra Karacaer, Selma Altındiş, Serap Gencer, Fatma Gümüşer, Serpil Erol, Hülya Özkan, Servet Öztürk, Serhat Birengel, Emine Parlak, Aysun Yalçı, Canan Ağalar, Selma Tosun, Mustafa Altındiş
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Objective : The aim of this study is to investigate the effects of some personal, environmental, social and disease-related factors on health-related quality of life (HRQOL) on people living with human immunodeficiency virus (PLWH). Methods : This study was carried out on PLWH over 18 years of age applying to infectious diseases and clinical microbiology outpatient clinics at eight centers in Turkey. Face-to-face interviews were conducted using General Information Form and Short Form-36 (SF-36)...
Topics: CD4 lymphocyte count, HIV, HIV RNA, quality of life, short form 36
Klimik Dergisi (Klimik Journal)
by Uğur Gönlügür, Mustafa Reşorlu, Alper Şener, Tanseli Gönlügür
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Abstract Bilateral multilobar ground-glass opacities are characteristic features of COVID-19 pneumonia. However, the differential diagnosis of ground-glass opacities is challenging. The aim of this paper was to share our experiences with other colleagues. The first patient presented with anosmia and loss of taste. Legionella antigen in urine was positive. The second patient had bilateral ground-glass opacities, which predominantly involved the upper lung zones and lymphopenia. Radiological...
Topics: computerized tomography, coronavirus, COVID-19, differential diagnosis
Abstract Objective: The study aims to contribute to the literature by sharing the treatment process and results of patients who develop pneumothorax, pneumomediastinum, and subcutaneous emphysema, which are rarely seen in COVID-19 pneumonia, and to reveal the possible high mortality situation. Methods: Patients whose COVID-19 polymerase chain reaction (PCR) swab test was positive and were diagnosed as COVID-19 pneumonia by thoracic computed tomography (CT) and who developed pneumothorax,...
Topics: Cilt Altı Amfizem, COVID-19, pneumomediastinum, pneumothorax, Pnömomediastinum, Pnömotoraks,...
Klimik Dergisi (Klimik Journal)
by Burcu Uysal, Necati Mumcu, Orhan Yıldız, Bilgehan Aygen
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Abstract Objective: The aim of the present study was to compare the new serological tests “immuncapture agglutination” (Brucellacapt, Vircell, Granada, Spain), enzyme-linked immunosorbent assay (ELISA) and the classical tests for diagnosis of acute, subacute or chronic brucellosis. Methods: Forty-nine samples of patients who presented with fever and clinical suspicion of brucellosis and who were admitted to Infectious Disease Department of Erciyes University Hospital with agglutination...
Topics: Brucellacapt test, Brucellacapt testi, brucellosis, Bruselloz, ELİSA, standard tube agglutination...
Klimik Dergisi (Klimik Journal)
by Hüseyin Avni Tarakçı, Altan Gökgöz, Süda Tekin
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Objective : Brucellosis is a zoonosis that affects more than 500 000 people a year, according to World Health Organization data. Brucellosis is endemic in Turkey, and it has a high morbidity. Community-based studies should be performed to detect brucellosis cases, to treat them, and to control the infection. The aim of this study was to determine the prevalence of brucellosis and the associated risks in adults aged 18 years and older living in Izmir. Methods : The study was carried out between...
Topics: Brocellosis, cpidemiologtj
Objective : Carbapenems are the most important broad spectrum antimicrobials used in the treatment of Acinetobacter baumannii infections, but resistance to carbapenems is increasing worldwide. In this study, we aimed to investigate the distribution of OXA-type carbapenemase genes observed in carbapenem-resistant A. baumannii strains by real-time polymerase chain reaction (PCR) method and to provide epidemiological data. Methods : Between January 2016 and January 2018, 20 carbapenem-resistant A....
Topics: Acinetobacter baumannii, OXAtype carbapenemase, realtime polymerase chain reaction
Klimik Dergisi (Klimik Journal)
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Broadly neutralizing antibodies (bNAbs) are monoclonal antibodies capable of inactivating a wide spectrum of HIV-1 subtypes and variants. These immunoglobulins were identified in 2009 in a small number of HIV-infected people. Their appearance during the process of natural infection was found to be substantially retarded and complicated. Vaccine applications have not been to produce such antibodies with sufficient properties. Thanks to the new technological advances, numerous neutralizing...
Topics: broadly neutralizing antibodies, HIV1, immunotherapy
Objective : Patients with chronic hepatitis B virus (HBV) infection that develop a superinfection due to hepatitis A virus (HAV), experience a more severe clinical picture compared to healthy individuals, and their underlying liver disease may exacerbate. Therefore, immunity to HAV should be investigated in patients with chronic HBV infection. In this study, it was aimed to investigate HAV serology among patients with chronic HBV infection, and to evaluate for immunization of seronegative...
Topics: Hepatitis A, Hepatitis B, immunization
Klimik Dergisi (Klimik Journal)
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Objective : In this study, we aimed to determine the epidemiology of hospital-acquired candidemia, its incidence, prevalence of known risk factors, species distribution, their antifungal susceptibilities, and impact on mortality in adult patients. Methods : Between August 1, 2014 and May 31, 2016, 102 patients over the age of 18 who were hospitalized in the intensive care unit and other inpatient clinics of Akdeniz University Hospital with Candida spp. growing in at least one blood culture...
Topics: Antifungal agents, Candida, candidemia
Klimik Dergisi (Klimik Journal)
by Rukiyye Bulut, Esma Kepenek Kurt, Bahar Kandemir, İbrahim Erayman, Mehmet Bitirgen
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Abstract Objective: Hepatitis B virus is an important health problem leading to chronic hepatitis, cirrhosis, and hepatocellular carcinoma. This study aimed to compare the efficacy and side effects of antiviral drugs used in chronic hepatitis B (CHB). Methods: Five hundred seventy-two patients who were followed and treated with CHB in our clinic were evaluated retrospectively. Results: Fifty-six point five of 572 patients were male, 43.5% were female, and the mean age of the patients was 43.4...
Topics: Chronic hepatitis B, entecavir, lamivudine, telbivudine
Klimik Dergisi (Klimik Journal)
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Invasive fungal infection (IFI) is a condition that develops among immunosupressed patients particularly and requires the prompt diagnosis and treatment. Histopathological examination and culture are the gold standards for the diagnosis, but difficulties in sampling and shortcomings of culture mandate use of easier and faster methods. Nowadays, molecular tests such as polymerase chain reaction are used in clinical practice in addition to serological tests. Combined use of these tests increase...
Topics: Aspergillus polymerase chain reaction, galactomannan, Invasive fungal infections, βDglucan
Klimik Dergisi (Klimik Journal)
by Halime Araz, Aysel Kocagül-Çelikbaş, Gülşen Hazırolan, Simten Dağdaş, Funda Ceran, Ebru Taşpınar, Merih Urlu, Kürşat Güneş, Gülsüm Özet
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In this report, we present a rare case of Aspergillus and Nocardia coinfection in a patient who underwent extensive immunosuppressive treatment due to graft versus host disease after allogeneic stem cell transplantation. We would like to emphasize the effect of targeted treatment on patient survival, and importance of collaboration between clinicians and laboratory professionals in providing early diagnosis even in rare infections. Klimik Dergisi 2019; 32(2): 195-9.
Topics: allogeneic stem cell transplantation, Aspergillus, coinfection, Nocardia
Klimik Dergisi (Klimik Journal)
by Mihriban Şengöz, Nihal Pişkin, Hande Aydemir, Füruzan Köktürk, İshak Özel Tekin, Güven Çelebi, Deniz Atakent
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Objective : Health care workers are exposed to many infectious agents when compared with general population. Immunization to vaccine-preventable diseases is an important part of infection control among health care workers, both for their own health and against the spread of infections. The aim of this study is to detect the immune status of health care workers of our hospital to measles, mumps, rubella (MMR) and varicella  and to define an appropriate vaccination program and also to analyze...
Topics: Health personnel, Seroprevalance, vaccination
Klimik Dergisi (Klimik Journal)
by Sevil Alkan-Çeviker, Özgür Günal, Süleyman Sırrı Kılıç
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Skin and soft tissue infections are most commonly caused by staphylococci or streptococci. Rarely, they can develop due to bacteria of the genus Aeromonas after contact with contaminated water and soil following trauma. A 75-year-old female diabetic patient applied to the infectious diseases outpatient clinic with complaints of swelling, pain, redness, tenderness, erythema and warmth in her lower leg. The patient had a skin deformity as a result of a previous traffic accident and she had gone...
Topics: abscess, Aeromonas hydrophila, Cellulitis, skin and soft tissue infections, thermal springs
Objective : With this study, it was aimed to research the implementations to prevent healthcare-associated infections (HAI) as well as their effectiveness in a private hospital in Turkey, where a high rate of HAI was reported with multidrug resistant pathogens. Methods : The study included all patients with HAI between January 1, 2011, and December 31, 2018. HAI rates were calculated according to the criteria of the Centers for Disease Control and Prevention. Infection control precautions were...
Topics: Healthcareassociated infections, Infection control
Klimik Dergisi (Klimik Journal)
by Çiğdem Kader, Ayşe Erbay, Mehmet Samet Demirel , Osman Kocabıyık , Elif Çiftçi , Nuriye Yalçın-Çolak , Güleser Ünsal , Şebnem Eren-Gök
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Abstract Objective: Healthcare professionals will be key to the success of COVID-19 vaccination programs because they are in the primary vaccination group. This study aims to measure and evaluate the acceptance, attitudes, and behaviors of healthcare professionals towards the COVID-19 vaccine. Methods: A questionnaire was applied to healthcare professionals via face-to-face interviews between 15-25 December 2020. Results: 507 participants were included in the study; the mean age was 31.6 ± 8.2...
Topics: COVID-19 vaccine, healthcare workers, vaccine hesitancy
Klimik Dergisi (Klimik Journal)
by Alpay Azap, Neyyire Yasemin Yalım, İsmail Cinel
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Abstract Intensive Care Units (ICU) are units where vital support with advanced technology is given to critically ill patients and multidisciplinary approaches are frequently applied. As we all see during the pandemic, the ICU beds are limited in number; therefore, appropriate use of ICU beds is very important to give the necessary treatment to patients on time while allocating the resources rationally and efficiently. Practices to be implemented for this purpose may cause conflicts between the...
Topics: Do-Not-Resuscitate Orders, futile treatment, intensive care units, potentially inappropriate...
Klimik Dergisi (Klimik Journal)
by Hüseyin Esmer, Salih Cesur, Metin Özsoy, Sami Kınıklı, Güler Vahaboğlu
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Herpes zoster develops following the reactivation of varicella zoster virus (VZV), and its location on sacral dermatome and consequential involvement of the genital area is a rare occurence. In this report, a 79-year-old male with genital herpes zoster was presented. It was mistaken initially for herpes genitalis, caused by herpes simplex virus (HSV) type 2, because of location of the rash. The patient’s serum antibodies have been found as follows anti-HSV type 2 IgM negative, anti-HSV type 2...
Topics: antiviral agents, genital area involvement, herpes zoster
Klimik Dergisi (Klimik Journal)
by Sinem Akkaya-Işık, Alper Gündüz, Ahsen Öncül, Aziz Ahmad Hamidi, Dilek Yıldız-Sevgi, Nuray Kes-Uzun, İlyas Dökmetaş
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Objective : The aim of this study was to evaluate demographic characteristics of patients with HIV infection applying to the Clinic of Infectious Diseases and Clinical Microbiology of İstanbul Şişli Hamidiye Etfal Training and Research retrospectively and to compare antiretroviral therapy (ART) regimens with regard to virological and immunological response in these patients. Methods : 196 HIV/AIDS patients who applied to the clinic between 2013 and 2015 were included in the study. Patients...
Topics: antiretroviral agents, HIV, immunological response, virological response
Klimik Dergisi (Klimik Journal)
by Muharrem Çiçek, Asiye Bıçakçıgil, Bekir Çelebi, Burçin Şener, Banu Sancak
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Misidentification of a blood culture isolate of Brucella melitensis as Roseomonas gilardii by the VITEK® MS (bioMérieux, Marcy l’Etoile, France) matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) microbial identification system is herein drawn attention. Blood and serum samples of a 42-year-old male with pre-diagnosed neurobrucellosis were evaluated in bacteriology and serology laboratories. Gram-negative coccobacilli from positive blood culture...
Topics: Brucella melitensis, MALDITOF MS, Roseomonas gilardii
Klimik Dergisi (Klimik Journal)
by Aslıhan Demirel, Nur Efe-İris, Esin Çevik, Safiye Koçulu, Arzu Baygül, Nuriye Taşdelen-Fışgın
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Objective : The aim of this study was to evaluate the catheter-related bloodstream infections (CR-BSI) devoloping in hematology and oncology departments, and intensive care units of three different hospitals from a clinical and microbiological point of view. Methods : We retrospectively evaluated the CR-BSI in hematology and oncology departments and intensive care units, and by using laboratory- and clinic-based active surveillance systems between January 2013 and December 2017 based on the...
Topics: Catheterrelated infections, port infection, surveillance
Klimik Dergisi (Klimik Journal)
by Özlem Yılmaz, Güven Çelebi, Erdinç Atabek, Füruzan Köktürk, Şahenis Deniz Atakent, Nihal Pişkin, Hande Aydemir
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Objective : Leptospirosis is one of the most common zoonotic diseases worldwide. Transmission to humans usually occurs by mucosal inoculation of the bacteria or exposure of non-intact skin via contact with water or soil contaminated with urine or feces of rodents. Occupational groups such as farmers, rice plant workers, sewer workers, miners, hunters, military personnel, mariners, shepherds, milkers, slaughterhouse workers, veterinarians and laboratory personnel are under risk for...
Topics: coal, leptospirosis, miners seroepidemiologic studies
Klimik Dergisi (Klimik Journal)
by Can Hüseyin Hekimoğlu, Esen Batır, Emine Yıldırım Gözel, Emine Alp Meşe
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Abstract Objective: Surgical site infection (SSI) surveillance is time-consuming and hard. Identifying high-risk patients and focusing on these patients will be cost and time effective. This study aims to develop a model to identify high-risk patients for the development of SSI after hip replacement surgery and to estimate the utility of the model. Methods: Logistic regression model was created to determine the risk of SSI development using the National Health Service Associated Surveillance...
Topics: hip replacement surgery, kalça protez ameliyatı, olasılık, probability, surgical site...
Klimik Dergisi (Klimik Journal)
by Pınar Yurdakul-Mesutoğlu, Şükran Yavuzdemir, Yasemin Ardıçoğlu-Akışın, Rabia Kahraman, Gülruhan Özcan, Oğuz Yüksel, Gözde Tekmen, Canberk Emri, Jülide Sedef Göçmen
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Objective : The aim of this study was to retrospectively analyse the data of patients with significant bacteriuria pre-diagnosed as urinary tract infection (UTI) and to compare the results with the current literature. Methods : A total of 2842 women, men, children, inpatients or outpatients with significant bacteriuria who were pre-diagnosed as UTI in TOBB University of Economics and Technology Faculty of Medicine Hospital between January 1, 2013 and December 31, 2017 were included in this...
Topics: age, Escherichia coli, sex, Urinary tract infections
Klimik Dergisi (Klimik Journal)
by Seniha Başaran, Halit Özsüt, A. Atahan Çağatay, Haluk Eraksoy
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Objective : In order to manage the antimicrobial treatment of patients with cholangitis/cholecystitis properly, it is very important to predict the potential causative pathogens and their antimicrobial resistance patterns. The aim of this study is to provide data for empirical treatment approaches by identifying the causative agents of biliary tract infections and their antimicrobial susceptibilities, and the risk factors in patients infected with drug-resistant microorganism. Methods :...
Topics: bile culture, Cholangitis, cholecystitis
Klimik Dergisi (Klimik Journal)
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Abstract Objective: Urinary tract infections (UTI) are the most common among the community and hospital-acquired infections. Escherichia coli is the most frequently isolated microorganism in UTIs. The treatment is mostly empirical. However, resistance related to the inappropriate use of antibiotics causes problems. Therefore, determining regional antibiotic resistance profiles and regular surveillance is essential. Therefore, we aimed to evaluate the distribution of strains and their resistance...
Topics: antimicrobial resistance, empiric treatment, urinary tract infection
Klimik Dergisi (Klimik Journal)
by Süda Tekin, Neşe Demirtürk
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Abstract Coronavirus disease 2019 (COVID-19), is caused by a novel coronavirus named as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). It became a major global health threat in a short time after being declared by the World Health Organization (WHO) as a pandemic on March 11, 2020. Viral, environmental, and host factors play a role in the course of COVID-19. The disease is more common in the elderly, men, and people with diabetes mellitus, hypertension, cardiovascular disease,...
Topics: co-morbidities, COVID-19, infection, risk factor, score system
Klimik Dergisi (Klimik Journal)
by Muharrem Güler, Meltem Avcı, Altan Gökgöz
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Objective : The aim of this study was to evaluate epidemiological, clinical, laboratory and treatment features and treatment response of brucellosis patients followed in a public hospital in the Eastern Anatolia. Methods : Ninety-six patients treated after the diagnosis of brucellosis were evaluated retrospectively. Results : The mean age of the patients was 53±33.9 years (range 15–84 years), and 55 (57%) of them were female. 36 (38%) of the patients were housewives, 17 (18%) were dealing...
Topics: Brocellosis, cpidemiologtj, diagnosis, treatment
Objective : Although there is no mandatory vaccination schedule for health care workers in Turkey, several vaccines such as seasonal influenza, tetanus, hepatitis B, measles-mumps-rubella (MMR), and varicella vaccines are recommended for all healthcare professionals. This study aimed to determine the attitudes and behaviors of health care workers to the recommended vaccines for themselves. Methods : The universe of cross-sectional study was 488 physicians and nurses working at the Faculty of...
Topics: attitude and behavior, Health personnel, risk assessment, vaccination
Klimik Dergisi (Klimik Journal)
by Enver Yüksel, Şafak Kaya, Emrah Günay, Eşref Araç
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Objective : Infections due to blood-borne viruses such as hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV), as well as bacterial infections are among important problems in hemodialysis patients. In this study, we aimed to determine the seroprevalence of HBV, HCV and HIV in patients undergoing hemodialysis, to reevaluate the patients susceptible to HBV, to screen isolated anti-HBc-positive patients for occult hepatitis B after identifying them. Methods :...
Topics: hemodialysis, Hepatitis B, hepatitis C, HIV, occult hepatitis B
Klimik Dergisi (Klimik Journal)
by Barış Ata Borsa, Zeynep Güngördü-Dalar, Asiye Karakullukçu, Veli Cengiz Özalp, Gökhan Aygün
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Objective : Antimicrobial resistance is one of the most important health problems of recent years. Multidrug-resistant Klebsiella pneumoniae strains have been causing serious problems in many countries including Turkey in recent years. Aim of this study was to detect molecular mechanisms behind the carbapenem resistance in carbapenem-resistant K. pneumoniae strains isolated from rectal swab samples and investigate the susceptibility of two potentially alternative drugs, fosfomycin, and...
Topics: carbapenems, chloramphenicol, Fosfomycin, Klebsiella pneumoniae
Klimik Dergisi (Klimik Journal)
by Sevil Alkan-Çeviker, Özgür Günal, Süleyman Sırrı Kılıç
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Objective : Urinary tract infection (UTI) often causes different clinical presentations ranging from asymptomatic bacteriuria which do not require treatment, to urosepsis requiring hospitalization in the intensive care unit. UTIs may lead to treatment failure, recurrence of infections or increased morbidity and mortality in the presence of complicating risk factors. The aim of this study was to evaluate the risk factors for the development of recurrent UTI (RUTI) in adults. Methods : The...
Topics: relapse, risk factors, urinary tract infection
Klimik Dergisi (Klimik Journal)
by Hatun Öztürk-Çerik, Şaban Esen, Betül Altıntaş-Öner, Merve Çelik, Tuğba Özdemir, Esra Tanyel
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Objective : Hepatitis C virus (HCV) infection is a global problem with personal, social and economic impacts. Approximately 85% of patients infected with HCV cannot achieve virus clearance. Cirrhosis, hepatocellular carcinoma and death may develop in patients with chronic infection.Until recently, treatments for chronic hepatitis C were difficult to use with many side effects, low treatment responses, and relapses. Direct-acting antivirals (DAAs) prevent HCV replication, and thir effectiveness...
Topics: dasabuvir, hepatitis C, Hepntitis C, ledipasvir, ombitasvir, paritaprevir, sofosbuvir
Klimik Dergisi (Klimik Journal)
by Pınar Korkmaz, Neşe Demirtürk, Ayşe Batırel, Necla Tülek, Müge Özgüler, Rezan Harman, Güle Çınar, Onur Toka, Gülşen Yörük, Çiğdem Ataman-Hatipoğlu, Figen Sarıgül, Fatma Sırmatel, Ayfer İmre, Duru Mıstanoğlu-Özatağ, Faruk Karakeçili, Onur Ural, Şua Sümer, Nazlım Aktuğ-Demir, Ayten Kadanalı, Şenol Çomoğlu, Sengül Üçer, Neşe Saltoğlu, Özgür Günal, Hacer Deniz Özkaya, Ercan Yenilmez, Rıza Aytaç Çetinkaya, Esma Yüksel, İsmail Necati Hakyemez, Meliha...
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Objective : Both chronic hepatitis B (CHB) and hepatosteatosis may lead to necroinflammation in liver. Therefore, the presence of hepatosteatosis might negatively affect the efficacy of antiviral therapy. We aimed to determine the effect of hepatosteatosis on virological response in patients with CHB receiving entecavir (ETV) and tenofovir (TDF) treatment. Methods : The study was designed retrospectively. All patients receiving antiviral therapy due to CHB in the departments of Infectious...
Topics: entecavir, Fatty liver, Tenofovir
Klimik Dergisi (Klimik Journal)
by Belgin Coşkun, Alpay Azap, Gülden Yılmaz, Müge Ayhan, Elif Mukime Sarıcaoğlu
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Objective : Colistin is a concentration-dependent antibiotic which belongs to the polymyxin group of cyclic cationic polypeptide antibiotics. Clinical use of colistin varies due to its complex pharmacokinetic and pharmacodynamic features. In this study, we aimed to evaluate the use of colistin in multidrug-resistant Gram-negative bacterial infections. Methods : 193 patients aged ≥18 years who were hospitalized from May 2014 to January 2015 and who received colistin were included in the study....
Topics: colistimethate sodium, colistin, Multiple bacterial drug resistance, nephrotoxicity
Klimik Dergisi (Klimik Journal)
by Sibel Yel, Ayşe Seda Pınarbaşı, Pınar Sağıroğlu, Mustafa Altay Atalay, Funda İpekten, İsmail Dursun
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Objective : In order to contribute the empirical treatment of urinary tract infections in children, the antibiotic resistance patterns of uropathogens isolated in one center over a year, and clinical risk factors were evaluated in this study. Methods : In this single-center study, the positive urine cultures and their antibiotic susceptibilities in a Child Nephrology Outpatient Clinic between March 2018 and March 2019 were evaluated retrospectively. Patient records, demographic data, obtaining...
Topics: childhood, microbial drug resistance, Urinary tract infections
Klimik Dergisi (Klimik Journal)
by Selin Büdeyri, Yasemin Zer, Özlem Keskin, Sevgi Bilgiç-Ertan
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Objective : Microorganisms that cause lung infections in cystic fibrosis (CF) are initially colonized in the upper respiratory tract mucosa and then pass into the lungs. In this study, we aimed to determine the pathogens colonized in the upper respiratory tract and the evaluation of phenotypic changes observed in these bacteria in patients with cystic fibrosis. Methods : Between May 2016 and May 2017 the routine respiratory tract samples (throat swab or sputum) taken from the patients who were...
Topics: Cystic fibrosis, Pseudomonas aeruginosa, respiratory tract infections, Staphylococcus aureus
Klimik Dergisi (Klimik Journal)
by Gürsel Ersan, Kazım Rollas, Sabri Atalay, Sarp Singil, Kâmil Mert, Hilal Abakay, Nimet Şenoğlu, Süheyla Serin-Senger, Şükran Köse
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Abstract Objective: In this study, we aimed to analyze real-time reverse transcription-polymerase chain reaction (RT-PCR) positive elderly patients (≥ 65 years old) admitted to the hospital with symptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection regarding their vaccination status. Methods: The study included 151 COVID-19 patients aged ≥ 65 years old, admitted to the hospital between March 10 and June 30, 2021. The study group was divided into two groups:...
Topics: COVID-19, Elderly population, inactive COVID-19 vaccines
Klimik Dergisi (Klimik Journal)
by Yahya Utlu, Okay Başak, Fürüzan Bozkurt-Kozan, M.Bülent Ertuğrul
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Objective : In this study, it was aimed to investigate the infecting agents and their resistance rates and to determine the risk factors with regard to growth of multidrug resistant (MDR) organisms in patients with diabetic foot infections. Methods : Follow-up forms of 114 diabetic foot patients who had completed their treatments at the care unit for chronic wounds, and their infections between September 2016 and August 2017 were evaluated retrospectively. According to the antimicrobial...
Topics: Diabetic foot, drug resistance
Klimik Dergisi (Klimik Journal)
by Betül Sadıç, Seniha Başaran, Serap Şimşek-Yavuz, Atahan Çağatay, Halit Özsüt, Haluk Eraksoy
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Objective : Recommended combination for the treatment of serious Stenotrophomonas maltophilia infections is ticarcillin-clavulanate and co-trimoxazole (SXT). However, first agent is not available in our country, and the second component may be a matter of antimicrobial resistance or intolerance.  Therefore, we aimed to evaluate antimicrobial susceptibility testing results of S. maltophilia and in vitro activity of ceftazidime and moxifloxacin as a potential therapeutic alternative. Methods :...
Topics: antimicrobial susceptibility, ceftazidime, drug combinations, Moxifloxacin, Stenotrophomonas...
Klimik Dergisi (Klimik Journal)
by Ülkü Öztoprak-Siyah, Kader Arslan, Salih Cesur, Çiğdem Ataman-Hatipoğlu, Şükran Sevim, Sami Kınıklı
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Legionella pneumophila, an etiologic agent of both community- and hospital-acquired pneumonia that can show serious course, and can be transmitted via aerosols from shower heads and air conditioners, and does not respond to β-lactam antibiotics. It can cause sporadic infections or epidemics. It can colonize in city waters, natural water sources such as thermal pools and humidifier water systems of air conditioners. In this report, a 54-year old male with L. pneumophila pneumonia presented with...
Topics: acute respiratory distress syndrome, Communityacquired pneumonia, Legionella pneumophila
Objective : Cystic fibrosis (CF) patients are exposed to respiratory system pathogens mostly forming biofilms, and therefore therapeutic interventions frequently fail. In this study, we aimed to investigate the resulting phenotypic changes in Pseudomonas aeruginosa due to interaction between bacteria and respiratory epithelium of CF patients. Methods : In vitro investigation of some phenotypic characteristics of P. aeruginosa such as biofilm formation, adhesion, and its growth rate was made in...
Topics: biofilms, Cystic fibrosis, Pseudomonas aeruginosa
Klimik Dergisi (Klimik Journal)
by Özlem Akdoğan, Derya Yapar, Tolga Düzenli, Gülcan Kaplan, Pınar Tunçel-Öztürk, Tuğba Özçerezci, Aysel Kocagül-Çelikbaş, Nurcan Baykam
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Cytomegalovirus (CMV) can cause severe, persistent, and even life-threatening diseases also affecting the gastrointestinal system in immunosuppressed individuals. Focal mucosal ulcerations and pseudopolyps were observed in the colonoscopy performed because of exacerbation of abdominal pain and bloody stools in a 71-year-old female followed by Gastroenterology Outpatient Clinic with ulcerative colitis for 7 years. Histomorphologic findings were compatible with ulcerative colitis. CMV...
Topics: Infliximab, ulcerative colitis
Klimik Dergisi (Klimik Journal)
by Orçun Barkay, Umut Devrim Binay, Özlem Gül, Faruk Karakeçili
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LETTER TO THE EDITOR
Topic: Letter To The Editor
Klimik Dergisi (Klimik Journal)
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Objective:  Optimizing colistin susceptibility testing has diffi- culties because of its high molecular weight and high binding capacity to polystyrene which is frequently used in antibiotic susceptibility testing. We aimed to compare the results of iso- lates, which were detected as colistin-resistant in the automat- ed system, obtained by using broth microdilution (BMD) meth- od which is the gold standard, with gradient diffusion method (GDM). Methods:  We investigated 36  Klebsiella...
Topics: Colistin-Resistant, Isolates in Automated System, Gradient Diffusion Method, Broth Microdilution...
Klimik Dergisi (Klimik Journal)
by Figen Sarıgül, Ülkü Üser, Nefise Öztoprak
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Objective : Coinfection of HIV and syphilis, especially in men who have sex with men has been increasing all over the world in recent years. We evaluated the seroprevalence of HIV/syphilis coinfections in patients followed by our clinic for the control of these diseases. Methods : A total of 384 HIV-infected patients followed between June 2015 and August 2018, and their sociodemographic characteristics such as age, gender, nationality, marital status, educational level, HIV and syphilis...
Topics: coinfection, HIV, seroepidemiologic studies, Syphilis
Klimik Dergisi (Klimik Journal)
by Selçuk Nazik, Perihan Öztürk, Duran Topak, Fatih Vatansever, Alper Ural, Ahmet Rıza Şahin, Selma Ateş, Hülya Nazik
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Necrotizing fasciitis is a serious soft tissue infection with rapidly spreading inflammation, thrombosis and necrosis affecting the skin, subcutaneous tissue and fasciae. The disease should be diagnosed early and appropriate antibiotherapy and surgical debridement should be applied. Delay in diagnosis or treatment significantly increases the morbidity and mortality of the disease. The aim of this report is to present a case with mortal necrotizing fasciitis in the light of the literature....
Topics: mortality, Necrotizing fasciitis, soft tissue infections
Klimik Dergisi (Klimik Journal)
by Pınar Şen, Tuna Demirdal, Salih Atakan Nemli
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Abstract Objectives: Streptococcus pneumoniae infections are an important cause of morbidity and mortality, especially among high-risk groups. Our country has limited data on the clinical findings of pneumococcal infections and invasive pneumococcal disease (IPD). Therefore, we aimed to evaluate patients’ demographic and clinical findings with pneumococcal infection. Methods: The data of the patients who were admitted to our hospital between January 2012 and December 2016 were analyzed...
Topics: invasive, Pneumococci, pneumococcus, risk factors, Streptococcus pneumonia
Klimik Dergisi (Klimik Journal)
by Emra Asfuroğlu-Kalkan, İrfan Soykan
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Abstract Objectives: Chronic hepatitis is a clinical and pathological condition defined by etiological, clinical, and pathological aspects, in which inflammation in the liver continues for more than six months. Hepatitis B virus is one of the most important causes of etiology. Although liver biopsy is accepted as the gold standard test, there is a need to search for an alternative method due to the risk of complications, invasiveness, and cost. Our aim in this study was; to evaluate the...
Topics: chronic hepatitis B, fibrosis, liver
Klimik Dergisi (Klimik Journal)
by Cumhur Özmen, Serap Şimşek-Yavuz, Seniha Başaran, Atahan Çağatay, Halit Özsüt, Haluk Eraksoy
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Abstract Objectives: We aimed to compare classical methods and chromogenic media to detect carbapenem-resistant Enterobacteriaceae (CRE) colonization among hospitalized patients and determine the risk factors causing infection in colonized patients. Methods: Between January and August 2017, 100 patients over the age of 18 who were hospitalized in the Reanimation Intensive Care Unit and the Trauma Emergency Intensive Care Unit of a university hospital were examined. From the first day of...
Topics: carbapenem, carbapenemase, rectal colonization
Klimik Dergisi (Klimik Journal)
by Lütfiye Nilsun Altunal, Mehtap Aydın, Ayşe Serra Özel, Gülsüm Çam, Kader Görkem Güçlü
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Abstract Objective: In this study, we aimed to determine the characteristics of patients with COVID-19 pneumonia who were hospitalized in our hospital in the first wave of the pandemic and the factors affecting the need for intensive care. Methods: Patients aged 18 years and older, hospitalized with the diagnosis of COVID-19 between 01/04/2020-30/06/2020 were included in the study. Demographic and clinical characteristics of the patients were reviewed retrospectively from their files....
Topics: COVID-19 pandemic, need for intensive care, risk factors
Klimik Dergisi (Klimik Journal)
by Harika Öykü Dinç, Sena Alkan, Doğukan Özbey, Serhat Sirekbasan, Nesrin Gareayaghi, Merve Cihan, Seher Akkuş, Bilgül Mete, Fehmi Tabak, Hrisi Bahar-Tokman, Bekir Kocazeybek
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Objective : We aimed to evaluate the presence of syphilis coinfection in HIV-infected individuals between January 2014 and December 2019. In addition, the data obtained from traditional and reverse algorithms for serological diagnosis of syphilis used consecutively in the same center were examined. Methods : Syphilis ELISA IgG (Vircell S.L., Granada, Spain), Elecsys® Syphilis (Roche Diagnostics, Mannheim, Germany) and TPHA (Spinreact, Girona, Spain) were used as treponemal tests in syphilis...
Topics: algorithms, HIV, Syphilis, Treponema pallidum
Klimik Dergisi (Klimik Journal)
by Esma Kepenek-Kurt, Bahar Kandemir, İbrahim Erayman, Rukiyye Bulut, Mehmet Bitirgen
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Objective : We aimed to analyse patients with Crimean-Congo haemorrhagic fever (CCHF) followed in our clinic. Methods : Clinical features, laboratory findings and treatments of 12 patients with CCHF followed between 2009 and 2018 were analysed retrospectively. Results : Mean age of the patients was 37.6±13.7 (ranges 17-59); 5 (42%) were female and 7 (58%) were male. All had a history of visit to the rural areas. Fever in 10 (83%) and fatigue in 6 (50%) patients were the most common symptoms....
Topics: cpidemiologtj, CrimeanCongo haemorrhagic fever virus
Klimik Dergisi (Klimik Journal)
by Mehmet Okan Yıldırım, Ömer Karaşahin
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Orf is a self-limiting and highly contagious infectious disease seen especially in farmers who deal with sheep and goats. Causative agent is orf virus which is a double stranded DNA virus from Parapoxvirus genus of Poxviridae family. Orf may be complicated by secondary bacterial infection, lymphadenopathy, lymphangitis and erythema multiforme. In this report, we present two cases of orf developed after contact with sheep and complicated by erythema multiforme.
Topic: erythema multiforme Orf
Klimik Dergisi (Klimik Journal)
by Fethiye Akgül, Serkan Sünger, Yusuf Arslan
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Sayın Editör, Tüm dünyada olduğu gibi Türkiye’de de, 2020 yılının başlarından itibaren COVID-19 pandemisi ile mücadele edilmektedir. Etkin bir tedavi bulunmamakla birlikte, birbirinden farklı teknolojiler kullanılarak geliştirilen aşılarla dünyada ve ülkemizde aşılama başlamış ve devam etmektedir. Hastalığı geçirerek toplum (kitle) bağışıklığının sağlanmasını beklemek yüz binlerce insanımızın kaybedilmesine neden olacaktır. Bu nedenle kitle...
Topics: Impact of Persuasion Teams, Vaccination Rate
Klimik Dergisi (Klimik Journal)
by Tülay Ünver-Ulusoy, Mesut Demirköse, Heval Can Bilek
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Abstract Objective: Severe respiratory syndrome Coronavirus-2 (SARS-CoV-2) caused a global pandemic that spread all over Turkey following the announcement of the first case on March 11, 2020. The present study aimed to investigate the diagnostic utility of complete blood count (CBC) parameters, C-reactive protein (CRP), and their ratios as well as their prediction on intensive care unit (ICU) admission among patients with Coronavirus Disease-2019 (COVID-19). Methods: We retrospectively...
Topics: C-reactive protein, C-reaktif protein, complete blood count, COVID-19, neutrophil/lymphocyte ratio,...
Klimik Dergisi (Klimik Journal)
by Perihan Erkan-Alkan, M. Ertan Güneş, Cüneyt Özakın, A. Ümit Sabancı
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Abstract Objective: In our study, a nanoparticle liposome molecule with patent application number TR201804452A2 was used, and the Minimum Inhibitor Concentration (MIC) was found to be 1562 ppm. According to the ASTM F 1980 standard, it has been determined that the nanoparticle liposome solution kept at 37 days and 55 o C in return for one-year stability preserves its effectiveness. Our study aimed to show that the newly developed solution maintains its effectiveness for a long time. Methods:...
Topics: antibacterial efficiency, Escherichia coli (ATCC 25922), Nanoparticle liposomes, ozone,...
Klimik Dergisi (Klimik Journal)
by Yusuf Ziya Demiroğlu, Ebru Oruç, İlker Ödemiş, Ziya Gökalp Bilgel
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Abstract Multisystem inflammatory syndrome in adults (MIS-A) is a rare condition that develops after coronavirus disease 2019 (COVID-19). We present two young adult male patients, aged 25 and 24 years, who admitted to our outpatient clinic with high fever, redness in the eyes, diarrhea, and maculopapular rash four weeks after after clinically mild COVID-19 infection. Echocardiography showed global hypokinesia in both cases. Therefore, the history of COVID-19 should be questioned, and the...
Topics: COVID-19, ejection fraction, MIS-A, myocarditis
Klimik Dergisi (Klimik Journal)
by Alpay Azap, İsmail Ağırbaş, Fügen Yörük, Neriman Defne Altıntaş, Mustafa Kemal Bayar, Ayşe Petek Bingöl
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Objective : The aim of this study is to determine the impact of identifying the causative agent from blood cultures on treatment cost among septic patients in intensive care units of a tertiary care hospital. Methods : A total of 88 sepsis episodes developing in 53 patients from December 2015 to March 2016 were evaluated retrospectively. Thirty-seven episodes in which the causative microorganisms were isolated from blood cultures (positive episode: case group) were compared with 37 episodes...
Topics: blood culture, cost and cost analysis, sepsis
Klimik Dergisi (Klimik Journal)
by Tuğba Çınar, Uğur Önal, Özgür Yalçınbayır, Halis Akalın
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Abstract Neuroretinitis is a rare presentation of cat-scratch disease caused by Bartonella henselae. In this case report, we aimed to describe a 46-year-old male patient who presented with acute visual loss and was diagnosed as neuroretinitis. Fundus examination showed evidence of optic disc edema, macular star, and peripapillary hemorrhagia. The serological tests were positive for Bartonella with both IgM and IgG titers as 1/320. He was successfully treated with doxycycline for eight weeks....
Topics: Bartonella henselae, cat-scratch disease, neuroretinitis
Klimik Dergisi (Klimik Journal)
by İsmail Türköz, Mehmet Ali Tüz, Emine Gencer, Fadime Özge Aygün-Kaş, Taner Yıldırmak
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While the COVID-19 pandemic which emerged in China at the end of 2019 and affected the whole world continues its effect all over the world; there are still questions in our minds regarding reinfection and prolonged infection. We report a case of COVID-19 reinfection detected in a patient presenting with similar symptoms approximately 5 months after the first infection.
Topics: COVID19, immunity, reinfection
Klimik Dergisi (Klimik Journal)
by Süda Tekin, Şua Sümer, Neşe Demirtürk, Bilgehan Aygen
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Abstract Corona virus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, affected all the world and has been a major cause for significant morbidity and mortality. COVID-19 represents with pulmonary manifestations, but in more than half of the cases, other organs, especially hepatic involvement, are observed. Chronic hepatitis C (CHC) is an important public health problem worldwide. Sustained virological response (SVR) can be achieved and...
Topics: Chronic hepatitis C, COVID-19, pandemi, pandemics
Objective : Hepatitis B virus (HBV) infection is a common cause of cirrhosis and hepatocellular carcinoma. Interferons and nucleos(t)ide analogs are being used for the treatment of chronic HBV infection. Entecavir (ETV) and tenofovir disoproxil fumarate (TDF) are the strongest oral antiviral agents. In this study, we aimed to investigate efficacy and safety of ETV and TDF in treatment of naive cirrhotic patients infected with HBV. Methods : A total of 58 cirrhotic patients infected with HBV who...
Topics: Chronic hepatitis B, cirrhosis, entecavir, Tenofovir
Klimik Dergisi (Klimik Journal)
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Objective : This study aims to evaluate the features of the patients diagnosed as herpes zoster who have suffered from pain for ≥3 months. Methods : 200 patients who have been suffered from pain due to herpes zoster for ≥3 months and were admitted to İstanbul Okmeydanı Training and Research Hospital Pain Clinic between January 2010 and August 2019 were evaluated retrospectively. Results : Of the 200 participant patients of this study, 108 (54%) were female and 92 (46%) were male. General...
Topics: herpes zoster postherpetic, neuralgia varicella, zoster virus
Klimik Dergisi (Klimik Journal)
by Esma Eren, İlhami Çelik, Merve Yıldız, Ulaş Serkan Topaloğlu, Ayşin Kılınç-Toker, Emine Arman-Fırat, Abdullah Gür, Elif Bolat, Ayşegül Ulu-Kılıç
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Objective : In this study, we aimed to determine the contact risk levels of infected health care workers for patients with COVID-19 and to evaluate their disease status. Methods : Health care workers with COVID-19 were analyzed, retrospectively. Close contact with patients was classified as high, medium, low-risk or risk-free contact according to the use of personal protective equipment, and transmission levels were evaluated. Symptoms and disease severity after infection were determined....
Topics: COVID19, healthcare workers, nosocomial transmission, personal protective equipment
Klimik Dergisi (Klimik Journal)
by Feyza İzci-Çetinkaya, Hatice Karagöz, Orhan Yıldız
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Objective : Since the first case from Wuhan, China in December 2019, COVID-19 has spread all over the world and a pandemic was declared by the World Health Organization on January 30, 2020. While there are no specific effective antiviral drugs or vaccines to treat or to prevent COVID-19; favipiravir, hydroxychloroquine and their combination are used in the treatment of COVID-19 in Turkey. In this study, it was aimed to evaluate the demographic, clinical and laboratory findings, the treatments...
Topics: COVID19, favipiravir, hydroxychloroquine, liver tests
Klimik Dergisi (Klimik Journal)
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Tularemia is a zoonotic disease which emerges as epidemics or sporadic cases and maintains its importance for public health. It can be confused with infectious and non-infectious diseases because of its clinical diversity, and invasive tests and unnecessary treatments can be applied to patients, especially in nonendemic areas, if it was not considered in differential diagnosis. The first case was referred to the outpatient clinic of infectious diseases and clinical microbiology to investigate...
Topics: Francisella tularensis, lymphadenopathy, tularemia
Abstract Objective: The European Norm (EN) 1500 standard, which was developed to evaluate the antibacterial efficacy of widely used hand rub agents, is the most common in vivo test method used in Europe and has been accepted by the Turkish Standards Institute. This study aimed to test five antiseptic products supplied from the market and the hand antiseptic formulation II recommended by the World Health Organization (WHO-II) for two application types using the EN 1500. Methods: In the first...
Topics: antibacterial efficacy, EN 1500, Hand antiseptics, WHO-recommended hand rub formulation
Klimik Dergisi (Klimik Journal)
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Abstract Objective: Tularemia is a zoonotic disease that causes epidemics in Turkey. An increase in tularemia cases was noticed in the province of Muş compared to previous years. With this study, we aimed to increase the awareness of tularemia in the region by sharing the characteristics of the cases. Methods: The epidemiological, demographic, and clinical characteristics of tularemia cases seen in the province of Muş between 2017-2019 were retrospectively analyzed. Only confirmed cases were...
Topics: epidemic, Francisella tularensis, Muş, oropharyngeal form, salgın, tularemia
Abstract Objective: Coronavirus disease 2019 (COVID-19) pandemic is a global health emergency. Physicians are at high risk for COVID-19 due to their occupational exposure to infected patients. In this study, we aimed to evaluate the opinions of physicians, who are at the forefront of the fight against the COVID-19 pandemic, on prophylaxis and probable vaccination for SARS-CoV-2 infection through a questionnaire. Methods: Between 25 July and 8 August 2020, survey questions were sent to message...
Topics: COVID-19, flu, influenza, prophylaxis, proplıyfaxis, vaccination, Vaccine
Klimik Dergisi (Klimik Journal)
by Merve Çağlar-Özer, Lütfiye Nilsun Altunal, Ayten Kadanalı
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Objective : This study aims to investigate the injuries exposing health care workers to blood and body fluids, distribution of such injuries by occupation and level of experience of the health care worker, and potential prevention strategies for reduction of such hazards. Methods : Our study was carried out in a 836-bed tertiary care education and research hospital that employs 3612 healthcare workers. Data from 116 sharps injuries, which occurred in our hospital in 2018, were retrospectively...
Topics: Health personnel, sharps injuries
Klimik Dergisi (Klimik Journal)
by Atakan Tekinalp, Taha Ulutan Kars, Hatice Zeynep Dikici, Sinan Demircioğlu, Özcan Çeneli
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Abstract Objective: The study aims to determine the frequency and clinical features of COVID-19 during the long-term follow-up of patients with hematological malignancies. Methods: Patients with hematological malignancies followed in our center were evaluated retrospectively. The patients were divided into two groups with having COVID-19 between April 01, 2020, and July 01, 2021: those who had COVID-19 [COVID (+)] and those who didn’t have COVID-19 [COVID (-)]. Results: 1258 patients were...
Topics: COVID-19, hematological malignancies, pandemi, pandemic, SARS-CoV-2
Klimik Dergisi (Klimik Journal)
by Bahar Akgün-Karapınar, Kutay Sarsar, Fatma Erdem, Derya Aydın
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Neisseria gonorrhoeae is one of the most important pathogenic microorganisms in sexually-transmitted diseases in the world. N. gonorrhoeae is an important problem for the community health due to the emerging resistance to antibiotics which has been used in the treatment in recent years, as well as the infections caused by it. When the antibiotic groups which were preferred in the past such as penicillins, tetracyclines, macrolides, trimethoprim-sulphametoxazole and quinolones are evaluated...
Topics: drug resistance, Neisseria gonorrhoeae
Klimik Dergisi (Klimik Journal)
by Tuğba Arslan-Gülen, Dilek Destegül, Refika Ortaköylü-Kılıçkaya, Ayfer İmre, Zuhal Atan-Uçar, Üner Kayabaş
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Despite improvements in medicine, tetanus is still a fatal infectious disease which can be prevented by immunoprophylaxis and it should always be kept in mind after injuries. In this case report, we present a patient who had no previous immunization history and did not have tetanus prophylaxis completed at the first visit of the emergency department after injury. The patient was followed with a clinical picture of generalized tetanus in intensive care unit, but autonomic dysfunction could not...
Topics: adult, fatality, immunization, Tetamıs