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Full text of "USPTO Patents Application 09864621"

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CLAIMS 



WHAT IS CLAIMED IS: 



A library of molecular profiles of chemical compositions having 



predetermined toxicities, produced by a method comprising the steps of: 

a) contacting an isolated mammaUan embryoid body with a chemical 
composition having predetermined toxicities; 



mammalian embryoid body in response to the chemical composition to create a molecular 
profile of the chemical composition; and 

c) compiling a library of molecular profiles by repeating steps a) and b) w^ith 
at least two chemical compositions having predetermined toxicities. 

2. The library of claim 1, wherein the isolated mammalian embryoid bodies are 
of human. 

3. The library of claim 2, fiirther wherein the chemical compositions having 
predetermined toxicities are selected firom the group consisting of therapeutic agents, 
neurotoxins, renal toxins, hepatic toxins, toxins of hematopoietic cells, and myotoxins. 

4. The library of claim 2, further wherein the chemical compositions having 
predetermined toxicities are selected fi^om the group consisting of agents that are toxic to 
cells of one or more reproductive organs, teratogenic agents and carcinogens. 

5. The library of claim 2, fiirther wherein the chemical compositions having 
predetermined toxicities are selected fi"om the group consisting of agricultural chemicals, 
cosmetics, and environmental contaminants. 

6. The library of claim 1, wherein the isolated mammalian embryoid bodies are 
of non-human mammals. 



b) recording alterations in gene expression or protein expressionan the 



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7. The library of claim 6, wherein the non-human manmials are rodents. 

8. The library of claim 6, further wherein the chemical compositions having 
predetermined toxicities are selected from the group consisting of animal therapeutics, 
neurotoxins, renal toxins, hepatic toxins, toxins of hematopoietic cells, and myotoxins. 



predetermined toxicities are selected from the group consisting of agents that are toxic to 



10. The library of claim 6, further wherein the chemical compositions having 
predetermined toxicities are selected from the group consisting of agricultural chemicals, 
cosmetics, and environmental contaminants. 

1 1 . The library of claim 1 , wherein the library comprises molecular profiles for at 
least 20 chemical compositions. 



9. 



The library of claim 6, further wherein the chemical compositions having 



cells of one or more reproductive organs, teratogenic agents and carcinogens. 




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