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SI 

?t sl/9/1 



PN="DE 19606207" 



1/9/1 

DIALOG (R) File 351:Derwent WPI 
(c) 2001 Derwent Info Ltd. All 



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011457374 

WPI Acc No: 1997-435281/199740 

XRAM Acc No: C97-139715 

XRPX Acc No: N97-362016 
Photo-toxicity and photosensitivity determination - comprises evaluation 
of effect of substance on embryo or tissue after contact and irradiation 
with electromagnetic radiation 

Patent Assignee: NEUMANN R J (NEUM-I) ; UNIV DUESSELDORF-HEINRICH-HEINE 
(UYDU-N) ; NEUMANN N J (NEUM-I) 

Inventor: HOIZIE E; LEHMANN P; NEUMANN R J; PLEWI6 G; ROSENBRUCH M; HOELZLE 
E; NEUMANN N J 

Number of Countries: 070 Number of Patents: 007 

Patent Family: 

£ind Date Applicat No Kind Date Week 

B 



Patent No 


Kind 


Date 


Applicat No 


Kind 


Date 


Week 


WO 


9731266 


Al 


19970828 


WO 


97EP508 


A 


19970205 


199740 


DE 


19606207 


Al 


19970828 


DE 


1006207 


A 


19960221 


199740 


AU 


9717217 


A 


19970910 


AU 


9717217 


A 


19970205 


199802 


EP 


883808 


Al 


19981216 


EP 


97904379 


A 


19970205 


199903 










WO 


97EP508 


A 


19970205 




EP 


883808 


Bl 


20000426 


EP 


97904379 


A 


19970205 


200025 










WO 


97EP508 


A 


19970205 




DE 


59701514 


G 


20000531 


DE 


501514 


A 


19970205 


200033 










EP 


97904379 


A 


19970205 












WO 


97EP508 


A 


19970205 




US 


6171858 


Bl 


20010109 


WO 


97EP508 


A 


19970205 


200104 










US 


99117797 


A 


19990311 





Priority Applications (No Type Date] 
Cited Patents: 4.Jnl.Ref; US 540536! 
Patent Details: 

Patent No Kind Lan Pg Main IPC 
WO 9731266 Al G 24 G01N-033/50 
Designated States (National) : AM 
DK EE ES FI GB GE HU IL JP KE KG 
MX NO NZ PL PT RO RU SD SE SG SI 
Designated States (Regional) : AT 
LS LU MC MW NL OA PT SD SE SZ UG 
DE 19606207 Al 7 G01N-021/75 

AU 9717217 A G01N-033/50 
EP 883808 Al G G01N-033/50 

Designated States (Regional) : AT 
EP 883808 Bl G G01N-033/50 

Designated States (Regional) : AT 
DE 59701514 G G01N-033/50 

US 6171858 Bl C12N-005/00 

Abstract (Basic): WO 9731266 A 

Phototoxicity and/or photos* 
or as a mixture) is determined ] 



: DE 1006207 A 19960221 
»; WO 9301272 

Filing Notes 

AT AU BA BB BG BR BY CA CH CN CU CZ DE 
KP KR KZ LC LK LR LT LU LV MD MG MN MW 
SK TJ TT UA US UZ VN YU 

BE CH DE DK EA ES FI FR GB GR IE IT KE 



Based on patent WO 9731266 

Based on patent WO 9731266 
BE CH DE ES FR GB IE IT LI LU NL 

Based on patent WO 9731266 
BE CH DE ES FR GB IE IT LI LU NL 

Based on patent EP 883808 

Based on patent WO 9731266 

Based on patent WO 9731266 

msitivity of substances (individually 



pa-622762 



Docket No. 441472000110 
U.S. Serial No.: 09/864,621 



(a) contacting the substance (s) either with a non-human vertebrate 
embryo or with tissue or cells from a vertebrate embryo (except human 
skin cell cultures) ; 

(b) irradiating with electromagnetic radiation in the range of 1 
mm- 200 nm, and 

(c) evaluating embryo, tissue or cell pathology. 

USE - The method is useful in investigating biologically active 
substances, especially pharmaceuticals, herbicides and insecticides, as 
well as light-screening substances. 

ADVANTAGE - The method is simple and satisfies ethical 
requirements * 

Dwg.0/0 

Title Terms: PHOTO; TOXIC; PHOTOSENSITISER; DETERMINE; COMPRISE; EVALUATE; 

EFFECT; SUBSTANCE; EMBRYO; TISSUE; AFTER; CONTACT; IRRADIATE; 

ELECTROMAGNET; RADIATE 
Derwent Class: B04; C07; D16; S03 

International Patent Class (Main): C12N-005/00; G01N-021/75; G01N-033/50 
International Patent Class (Additional): C12N-005/06; C12Q-001/00; 

C12Q-001/02; G01N-033/15; G01N-033/483 
File Segment: CPI; EPI 

Manual Codes (CPI/A-N) : B04-F07; C04-F07; B06-A03; C06-A03; B11-C07B2; 

C11-C07B2; B12-K04A; C12-K04A; D05-H09 
Manual Codes (EPI/S-X) : S03-E14H 
Chemical Fragment Codes (Ml) : 

*01* M423 M760 M903 N102 Q233 V600 V614 V644 V645 V754 
Chemical Fragment Codes (M6) : 

*02* M903 Q233 R515 R614 R627 R633 R636 R639 
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